Effects of Nafamostat Mesilate and Syste

IF 0.8 4区医学 Q4 UROLOGY & NEPHROLOGY

Iranian journal of kidney diseases Pub Date : 2025-02-25 DOI:10.52547/5j9v7385

引用次数: 0

Abstract

Introduction: To investigate the effect of continuous renal replacement therapy (CRRT) in patients with severe acute kidney injury (AKI) by using Nafamostat Mesilate (NM). Methods. Eighty patients with AKI who underwent CRRT from March 2022 to January 2022 were divided into control group (n = 40, treated with unfractionated heparin) and Observation group (n = 40, treated with NM). The duration of the first filter use, the number of filters used 72 hours after treatment, coagulation and renal functions, adverse reactions, bleeding events, length of stay in intensive care unit (ICU)

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甲磺酸纳莫司他与全身无分级肝素抗凝对危重AKI CRRT患者凝血、肾功能和28天生存状态的影响

前言：探讨重度急性肾损伤（AKI）患者应用甲磺酸那莫他（NM）进行持续肾替代治疗（CRRT）的效果。方法。将2022年3月至2022年1月行CRRT治疗的AKI患者80例分为对照组（n = 40，采用未分割肝素治疗）和观察组（n = 40，采用NM治疗）。比较两组患者首次使用过滤器的时间、治疗后72小时使用过滤器的次数、凝血功能和肾功能、不良反应、出血事件、重症监护病房（ICU）住院时间和28天的生存状况。结果。观察组第一次滤芯使用时间较对照组长，治疗72 h后滤芯使用次数少于对照组（P < 0.05）；与治疗前比较，观察组和对照组患者治疗48 h后纤维蛋白原（FIB）、血小板计数（PLT）水平均下降，活化部分凝血活酶时间（APTT）、凝血酶原时间（PT）、凝血酶时间（TT）、国际标准化比值（INR）水平升高。但前者FIB、PLT水平较高，APTT、PT、TT、INR水平较低（P < 0.05）；与治疗前比较，观察组和对照组治疗48 h后肌酐（Scr）、尿素氮（BUN）、血清胱抑素C （CysC）水平均下降，其中观察组更低（P < 0.05）；观察组患者出血事件发生率低于对照组，ICU住院时间短于对照组，28天生存率高于对照组（P < 0.05）。两组不良反应比较，差异无统计学意义（P < 0.05）。结论：NM可改善重度AKI行CRRT患者的凝血功能和肾功能，延长滤器使用时间，减少滤器使用次数，缩短ICU住院时间，减少出血事件的发生，改善预后。

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来源期刊

Iranian journal of kidney diseases UROLOGY & NEPHROLOGY-

CiteScore

2.50

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： The Iranian Journal of Kidney Diseases (IJKD), a peer-reviewed journal in English, is the official publication of the Iranian Society of Nephrology. The aim of the IJKD is the worldwide reflection of the knowledge produced by the scientists and clinicians in nephrology. Published quarterly, the IJKD provides a new platform for advancement of the field. The journal’s objective is to serve as a focal point for debates and exchange of knowledge and experience among researchers in a global context. Original papers, case reports, and invited reviews on all aspects of the kidney diseases, hypertension, dialysis, and transplantation will be covered by the IJKD. Research on the basic science, clinical practice, and socio-economics of renal health are all welcomed by the editors of the journal.