Co-occurring impairments in several domains of memory following neonatal hypoxic-ischaemic encephalopathy have real-life implications

Abstract

Background

Neonatal Hypoxic-Ischaemic Encephalopathy (HIE) increases the risk for neurodevelopmental impairment. Information on school-age memory function is limited in children who received hypothermia treatment (TH) for neonatal HIE.

Objectives

To evaluate memory function in school-aged children who had neonatal HIE and TH and survived without major neuromotor impairment.

Method

Fifty-one children with neonatal HIE and 41 typically developing (TD) peers participated. At age 6–8 years general cognitive abilities (FSIQ) were assessed with Wechsler Intelligence Scale for Children (WISC-V), immediate and delayed visual and verbal memory with Children's Memory Scale (CMS), everyday memory with Rivermead Behavioural Memory Test for Children (RBMT-C), and working memory with WISC-V. Real-life implications were assessed with Behavior Rating Inventory for Executive Function (BRIEF; Parent and Teacher). Group differences were examined and correlations calculated to assess associations between memory measures. Relationship maps illustrate co-occurring impairments.

Results

FSIQ was in the normal range for both groups but significantly lower in the HIE group. Children with HIE had significantly more deficits in working memory (20.4 % vs 0 %), verbal immediate (20.0 % vs 2.5 %), verbal delayed (17.8 % vs 2.5 %), visual immediate (28.9 % vs 7.5 %), and everyday memory (38.8 % vs 5.6 %). Relationship maps identified more co-occurring clinical/borderline impairments in children with HIE (45.1 % vs 4.9 %) and more frequent clinical impairments in real-world memory measures.

Conclusion

Despite hypothermia treatment, and with general cognitive abilities in the normal range, children with neonatal HIE are at risk of memory impairments in multiple domains, affecting everyday functioning at home and school. Timely identification is important for individually targeted support.