KIFC1 in cancer: Understanding its expression, regulation, and therapeutic potential

IF 3.3 3区生物学 Q3 CELL BIOLOGY

Experimental cell research Pub Date : 2025-03-08 DOI:10.1016/j.yexcr.2025.114510

Gaurav Sanghvi , R. Roopashree , Aditya Kashyap , A. Sabarivani , Subhashree Ray , Pushpa Negi Bhakuni

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引用次数: 0

Abstract

Kinesins are a family of motor proteins essential for intracellular transport and cellular dynamics, with kinesin family member C1 (KIFC1) emerging as a key regulator of cancer progression. Recent studies highlight KIFC1's crucial role in mitotic spindle assembly, chromosome segregation, and cell migration—processes frequently dysregulated in cancer. Its involvement in promoting malignant cell proliferation and metastasis underscores its significance in tumor biology. In various cancer types, aberrant KIFC1 expression correlates with poor prognosis and aggressive phenotypes, suggesting its potential as a biomarker for disease severity. Mechanistically, KIFC1 influences signaling pathways linked to cell cycle regulation and programmed cell death, reinforcing its role in oncogenesis. Given its pivotal function in cancer cell dynamics, KIFC1 represents a promising therapeutic target. Strategies aimed at modulating its activity, including small molecules or RNA interference, could disrupt cancer cell viability and proliferation. The current review article highlights KIFC1's importance in cancer biology, advocating for further investigation into its mechanisms and the development of KIFC1-targeted therapies to enhance treatment efficacy and improve patient outcomes across various malignancies.

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癌症中的KIFC1：了解其表达、调节和治疗潜力

运动蛋白是一个对细胞内运输和细胞动力学至关重要的运动蛋白家族，其中运动蛋白家族成员C1 （KIFC1）成为癌症进展的关键调节因子。最近的研究强调了KIFC1在有丝分裂纺锤体组装、染色体分离和细胞迁移过程中的关键作用，这些过程在癌症中经常失调。它参与促进恶性细胞的增殖和转移，强调了它在肿瘤生物学中的重要性。在各种癌症类型中，异常的KIFC1表达与不良预后和侵袭性表型相关，这表明它有可能作为疾病严重程度的生物标志物。在机制上，KIFC1影响与细胞周期调节和程序性细胞死亡相关的信号通路，加强其在肿瘤发生中的作用。鉴于其在癌细胞动力学中的关键功能，KIFC1代表了一个有希望的治疗靶点。旨在调节其活性的策略，包括小分子或RNA干扰，可能会破坏癌细胞的生存能力和增殖。当前的综述文章强调了KIFC1在癌症生物学中的重要性，提倡进一步研究其机制和开发KIFC1靶向治疗，以提高各种恶性肿瘤的治疗效果和改善患者预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Experimental cell research 医学-细胞生物学

CiteScore

7.20

自引率

0.00%

发文量

295

审稿时长

30 days

期刊介绍： Our scope includes but is not limited to areas such as: Chromosome biology; Chromatin and epigenetics; DNA repair; Gene regulation; Nuclear import-export; RNA processing; Non-coding RNAs; Organelle biology; The cytoskeleton; Intracellular trafficking; Cell-cell and cell-matrix interactions; Cell motility and migration; Cell proliferation; Cellular differentiation; Signal transduction; Programmed cell death.