Suzuki coupling reaction catalyzed by biosynthesized of gold nanoparticles in water under ultrasonic conditions and its application for treatment of bladder cancer

IF 2.1 3区化学 Q3 CHEMISTRY, INORGANIC & NUCLEAR

Journal of Organometallic Chemistry Pub Date : 2025-03-01 DOI:10.1016/j.jorganchem.2025.123597

Jie Liu , Liqing Guo

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Abstract

Recently, coupled bio-nanomaterials containing gold nanoparticles have attracted attention as a potentially useful platform for biological composites of the future. Accordingly, we reported a new anticancer agent (Au NPs@GG) supported by Au NPs under sonication energy. Many physicochemical techniques, including UV–Vis spectroscopy, FESEM, TEM, EDX, XRD, and ICP-OES, were used to thoroughly analyze the prepared desired nanocomposite. The material was catalytically explored in the Suzuki-Miyaura coupling for synthesis of different biaryl compounds under aqueous conditions. The catalyst, Au NPs@GG, resulted the related products in good yields at short reaction times. Furthermore, one of the widely utilized antioxidant techniques, DPPH, was employed to study the antioxidant potential of Au NPs@GG. The DPPH test findings demonstrated that Au NPs@GG had superior antioxidant qualities when compared to the controls. The antioxidant test revealed that Au NPs@GG had an IC₅₀ of 135 µg/mL. The Au NPs@GG nanocomposite showed no cytotoxicity on the normal cell line, while its cell viability against bladder cancer (5637 and TCCSUP) cell lines was extremely low. The TCCSUP cell line exhibited the best anti-human bladder cancer characteristics of the nanocomposite when compared to the aforementioned cell lines. The nanocomposite may be used to treat various forms of bladder cancer in people, based on the results given above.

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来源期刊

Journal of Organometallic Chemistry 化学-无机化学与核化学

CiteScore

4.40

自引率

8.70%

发文量

221

审稿时长

36 days

期刊介绍： The Journal of Organometallic Chemistry targets original papers dealing with theoretical aspects, structural chemistry, synthesis, physical and chemical properties (including reaction mechanisms), and practical applications of organometallic compounds. Organometallic compounds are defined as compounds that contain metal - carbon bonds. The term metal includes all alkali and alkaline earth metals, all transition metals and the lanthanides and actinides in the Periodic Table. Metalloids including the elements in Group 13 and the heavier members of the Groups 14 - 16 are also included. The term chemistry includes syntheses, characterizations and reaction chemistry of all such compounds. Research reports based on use of organometallic complexes in bioorganometallic chemistry, medicine, material sciences, homogeneous catalysis and energy conversion are also welcome. The scope of the journal has been enlarged to encompass important research on organometallic complexes in bioorganometallic chemistry and material sciences, and of heavier main group elements in organometallic chemistry. The journal also publishes review articles, short communications and notes.