Leukocyte poor platelet rich plasma vs leukocyte rich platelet rich plasma as a treatment for cervical facetogenic pain: A pooled analysis

David J. Allison , Eldon Loh , Robert Burnham , Taylor Burnham , Ashley Smith
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Abstract

Background

This study aimed to compare the effectiveness and safety of leukocyte-poor platelet-rich plasma (LP-PRP) and leukocyte-rich platelet-rich plasma (LR-PRP) for the treatment of cervical facetogenic pain through a pooled analysis of two independent studies. The goal was to provide preliminary evidence comparing the effect on pain relief and functional improvement over time to help inform future research.

Methods

The pooled analysis integrated data from two studies: a prospective case series of LR-PRP (n = 36) and a randomized controlled trial (RCT) comparing LP-PRP (n = 21) with corticosteroid injections. Participants in both studies had chronic cervical facetogenic pain confirmed through medial branch blocks and were assessed at baseline, 3 months, and 6 months post-injection. Pain intensity was measured using the Numerical Pain Rating Scale (NRS), and functional disability was assessed using the Neck Disability Index (NDI). Linear mixed-effects models evaluated treatment effects over time, controlling for age, sex, and pain duration. Clinically important differences in pain and disability were determined. Adverse events were also recorded.

Results

Both PRP groups exhibited significant improvements in pain and functional outcomes. However, LR-PRP demonstrated superior efficacy at 6 months, with a greater reduction in NRS scores (β = −1.68, p < 0.01, Cohen's d = −1.15) and NDI scores (β = −3.66, p = 0.02, Cohen's d = −0.94) compared to LP-PRP. A higher proportion of LR-PRP participants achieved clinically significant pain relief (≥2-point NRS reduction) and functional improvement (≥10 % NDI reduction) at 6-months. No significant differences were observed at 3 months. Adverse events were more common in the LP-PRP group, with 11 documented cases, including increased pain and muscle spasms, whereas the LR-PRP group reported no adverse events.

Conclusion

These preliminary findings suggest that LR-PRP appears to provide greater long-term benefits for cervical facetogenic pain compared to LP-PRP, with superior pain reduction, improved function, and a favorable safety profile. These findings suggest the higher leukocyte concentration in LR-PRP may enhance therapeutic outcomes for cervical pain. Further large-scale, randomized trials are necessary to confirm these results and establish standardized PRP preparation protocols.
背景本研究旨在通过对两项独立研究的汇总分析,比较贫白细胞富血小板血浆(LP-PRP)和富白细胞富血小板血浆(LR-PRP)治疗颈椎面源性疼痛的有效性和安全性。汇总分析整合了两项研究的数据:LR-PRP 的前瞻性病例系列(n = 36)和比较 LP-PRP (n = 21)与皮质类固醇注射的随机对照试验(RCT)。两项研究的参与者均为慢性颈椎面源性疼痛,经内侧支阻滞证实,并在基线、注射后 3 个月和 6 个月接受评估。疼痛强度采用数字疼痛评定量表(NRS)进行测量,功能障碍采用颈部残疾指数(NDI)进行评估。线性混合效应模型评估了随时间变化的治疗效果,并控制了年龄、性别和疼痛持续时间。确定了疼痛和残疾的临床重要差异。结果两组 PRP 均显著改善了疼痛和功能结果。然而,与 LP-PRP 相比,LR-PRP 在 6 个月时的疗效更佳,NRS 评分(β = -1.68, p < 0.01, Cohen's d = -1.15 )和 NDI 评分(β = -3.66, p = 0.02, Cohen's d = -0.94)降低幅度更大。在6个月时,更多的LR-PRP参与者实现了临床上显著的疼痛缓解(NRS评分降低≥2分)和功能改善(NDI评分降低≥10%)。3个月时未观察到明显差异。LP-PRP组的不良反应更常见,有11例记录在案,包括疼痛加剧和肌肉痉挛,而LR-PRP组未报告任何不良反应。结论这些初步研究结果表明,与LP-PRP相比,LR-PRP似乎对颈椎面源性疼痛有更大的长期疗效,能更好地减轻疼痛、改善功能并具有良好的安全性。这些研究结果表明,LR-PRP 中的白细胞浓度较高,可能会提高颈椎疼痛的治疗效果。有必要进一步开展大规模随机试验来证实这些结果,并制定标准化的 PRP 制备方案。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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