Chikungunya virus in Europe: A retrospective epidemiology study from 2007 to 2023.

IF 3.4 2区医学 Q1 PARASITOLOGY

PLoS Neglected Tropical Diseases Pub Date : 2025-03-07 eCollection Date: 2025-03-01 DOI:10.1371/journal.pntd.0012904

Qian Liu, Hong Shen, Li Gu, Hui Yuan, Wentao Zhu

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引用次数: 0

Abstract

Background: Chikungunya virus (CHIKV), a mosquito-borne alphavirus, is responsible for disease outbreaks worldwide. However, systematic knowledge of spatiotemporal distribution and risk patterns of CHIKV in mainland Europe remains unclear. Our aim was to decipher the epidemiological characteristics, diversity, and clinical manifestations of CHIKV.

Methods: In this retrospective study, we retrieved the surveillance bulletins of chikungunya infections reported in Europe during 2007-2023 to depict the epidemiological characteristics. We performed genotyping and phylogenetic analyses to examine the evolution and mutation. We also searched PubMed, Web of Science, and Google Scholar to conduct meta-analyses of clinical manifestations.

Results: 4730 chikungunya cases across twenty-two countries were documented in mainland Europe from 2007-2022, with no cases reported in 2023. The age-standardized incidence rate was highest in 2014 (0.31), with significant variations observed in each country per year. Although autochthonous outbreaks occurred in several countries, the majority of cases were travel-related, with individuals mainly getting infected during summer vacation. Most travel-related cases were reported as being acquired in India (11.7%), followed by Dominican Republic (9.0%), Guadeloupe (8.7%), and Thailand (7.8%). Genotyping of genome sequences identified two genotypes, with the majority belonging to II-ECSA. The E1 A226V mutation was detected from autochthonous outbreaks, including Italy in 2007 and France in 2014 and 2017. The most common symptoms reported were fever (97.6%), joint pain (94.3%), fatigue (63.5%), and skin rash (52.3%).

Conclusion: The suitable niches for CHIKV are expanding due to climate change and global travel. With the absence of specific antiviral treatments and vaccines still in development, surveillance and vector control are essential in suppressing the re-emergence and epidemics of CHIKV.

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基孔肯雅病毒在欧洲：2007年至2023年的回顾性流行病学研究

背景：基孔肯雅病毒（CHIKV）是一种蚊媒甲病毒，是造成世界范围内疾病暴发的原因。然而，对欧洲大陆CHIKV的时空分布和风险模式的系统认识仍然不清楚。我们的目的是破译CHIKV的流行病学特征、多样性和临床表现。方法：回顾性分析2007-2023年欧洲报告的基孔肯雅热感染监测公报，描述其流行病学特征。我们进行了基因分型和系统发育分析，以检查进化和突变。我们还检索PubMed、Web of Science和b谷歌Scholar对临床表现进行meta分析。结果：2007-2022年在欧洲大陆22个国家记录了4730例基孔肯雅热病例，2023年没有报告病例。年龄标准化发病率在2014年最高（0.31），每个国家每年都有显著差异。虽然在一些国家发生了本地暴发，但大多数病例与旅行有关，个人主要在暑假期间感染。大多数报告的旅行相关病例发生在印度（11.7%），其次是多米尼加共和国（9.0%）、瓜德罗普岛（8.7%）和泰国（7.8%）。基因组序列基因分型鉴定出2种基因型，多数属于ii型ecsa。E1 A226V突变是在本土暴发中发现的，包括2007年的意大利和2014年和2017年的法国。报告的最常见症状为发热（97.6%）、关节疼痛（94.3%）、疲劳（63.5%）和皮疹（52.3%）。结论：由于气候变化和全球旅游的影响，CHIKV的适宜生境正在扩大。由于缺乏特异性抗病毒治疗和仍在开发中的疫苗，监测和病媒控制对于抑制CHIKV的再次出现和流行至关重要。

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来源期刊

PLoS Neglected Tropical Diseases PARASITOLOGY-TROPICAL MEDICINE

自引率

10.50%

发文量

723

期刊介绍： PLOS Neglected Tropical Diseases publishes research devoted to the pathology, epidemiology, prevention, treatment and control of the neglected tropical diseases (NTDs), as well as relevant public policy. The NTDs are defined as a group of poverty-promoting chronic infectious diseases, which primarily occur in rural areas and poor urban areas of low-income and middle-income countries. Their impact on child health and development, pregnancy, and worker productivity, as well as their stigmatizing features limit economic stability. All aspects of these diseases are considered, including: Pathogenesis Clinical features Pharmacology and treatment Diagnosis Epidemiology Vector biology Vaccinology and prevention Demographic, ecological and social determinants Public health and policy aspects (including cost-effectiveness analyses).