Ongoing outbreak of maternal parvovirus B19 infections in Germany since end of 2023: consequence of COVID-19 pandemic?

IF 6.1 1区医学 Q1 ACOUSTICS

Ultrasound in Obstetrics & Gynecology Pub Date : 2025-04-01 Epub Date: 2025-03-06 DOI:10.1002/uog.29197

J Jiménez Cruz, R Axt-Fliedner, C Berg, F Faschingbauer, K O Kagan, J Knabl, A Lauten, H Lehmann, H Stepan, M Tavares de Sousa, S Verlohren, U Germer, J Weichert, B Strizek, A Geipel

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引用次数: 0

Abstract

Objective: To investigate the ongoing parvovirus B19 (B19V) outbreak among pregnant women in Germany and its connection to the coronavirus disease 2019 (COVID-19) pandemic.

Methods: This retrospective cohort study analyzed anonymous data regarding serologically confirmed B19V infections during pregnancy between January 2014 and April 2024 across 13 major fetal medicine centers in Germany. We evaluated the yearly frequency of B19V cases, cases that underwent intrauterine transfusion (IUT), cases presenting with hydrops fetalis and cases of intrauterine fetal death (IUFD) related to B19V infection, and stratified these variables by event occurrence < 20 weeks' gestation or ≥ 20 weeks' gestation. Variables were compared across three subperiods: pre COVID-19 pandemic, during the COVID-19 pandemic and post COVID-19 pandemic.

Results: Data from 918 pregnant women with confirmed B19V infection revealed a significant B19V outbreak since the end of 2023. The mean ± SD number of annual cases was 57.3 ± 20.7 pre COVID-19, 20.3 ± 13.5 during COVID-19 and surged to 384.8 ± 299.8 post COVID-19 (P < 0.01). Correspondingly, the number of cases in which the fetus underwent IUT increased post COVID-19. The proportion of B19V diagnoses made before 20 weeks' gestation increased from 32.3% pre COVID-19 to 53.2% post COVID-19 (P < 0.001).

Conclusions: These results demonstrate an unforeseen increase in B19V infections during pregnancy after the COVID-19 pandemic, with a consequent rise in B19V cases with fetal anemia. The introduced policies during the COVID-19 pandemic reduced the B19V infection rate but likely conditioned the present ongoing upsurge. Counseling, early detection and access to specialized centers performing IUT are essential measures required to address this outbreak. © 2025 The Author(s). Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.

查看原文本刊更多论文

自2023年底以来德国持续爆发的母体细小病毒B19感染：COVID-19大流行的后果？

目的：了解德国孕妇中正在发生的细小病毒B19 （B19V）疫情及其与2019冠状病毒病（COVID-19）大流行的关系。方法：本回顾性队列研究分析了德国13个主要胎儿医学中心2014年1月至2024年4月期间妊娠期血清学确诊B19V感染的匿名数据。我们评估了与B19V感染相关的B19V病例、宫内输血（IUT）病例、胎儿水肿病例和宫内死胎（IUFD）病例的年发生率，并根据事件发生率对这些变量进行了分层。结果：918例确诊B19V感染的孕妇的数据显示，自2023年底以来，B19V发生了显著的暴发。年平均±SD病例数为新冠肺炎前57.3±20.7例，新冠肺炎期间为20.3±13.5例，新冠肺炎后为384.8±299.8例(P)。结论：新冠肺炎大流行后妊娠期B19V感染意外增加，B19V合并胎儿贫血的病例也随之增加。在2019冠状病毒病大流行期间采取的政策降低了B19V感染率，但可能制约了目前的持续上升。咨询、早期发现和进入实施IUT的专业中心是应对这一疫情所需的基本措施。©2025作者。妇产科学超声由John Wiley & Sons Ltd代表国际妇产科学超声学会出版。

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来源期刊

Ultrasound in Obstetrics & Gynecology 医学-妇产科学

CiteScore

12.30

自引率

14.10%

发文量

891

审稿时长

1 months

期刊介绍： Ultrasound in Obstetrics & Gynecology (UOG) is the official journal of the International Society of Ultrasound in Obstetrics and Gynecology (ISUOG) and is considered the foremost international peer-reviewed journal in the field. It publishes cutting-edge research that is highly relevant to clinical practice, which includes guidelines, expert commentaries, consensus statements, original articles, and systematic reviews. UOG is widely recognized and included in prominent abstract and indexing databases such as Index Medicus and Current Contents.