Brugada Phenocopy due to Hyponatremia: A Case Report and Review of the Literature.

Abstract

Brugada phenocopy (BrP) is the electrocardiographic appearance of a Brugada pattern due to various reversible causes that is completely resolved after the correction of the underlying abnormalities. In this short communication, we describe a 56-year-old man who had a transient BrP induced by hyponatremia due to thiazide diuretic therapy. A detailed review of the literature revealed that hyponatremia represents an uncommon cause of BrP while, in many of the published cases, concomitant electrolyte disturbances such as hyperkalemia were present. However, even isolated hyponatremia may provoke a BrP. Clinicians should be aware of this rare cause of BrP, which is reversible and has a favorable outcome.