MRI evaluation of Pacinian corpuscle number and distribution in the forefoot in diabetic sensorimotor polyneuropathy.

IF 4.1 2区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Insights into Imaging Pub Date : 2025-03-07 DOI:10.1186/s13244-025-01932-8

Sophia S Goller, Georg C Feuerriegel, Adrian A Marth, Christoph Germann, Martin Schubert, Michèle Hubli, Felix W A Waibel, Reto Sutter

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引用次数: 0

Abstract

Objectives: To evaluate Pacinian corpuscles (PC) in the forefoot of patients with type 2 diabetes-derived sensorimotor polyneuropathy (DSP) with MRI.

Materials and methods: This single-center study compared 20 DSP patients who underwent clinical forefoot 3-T MRI to healthy volunteers matched for age and gender. Two radiologists independently assessed the number and distribution of PC. In addition, one radiologist determined PC size. Correlations between PC number, duration of diabetes, and Hemoglobin A1c (HbA1c) were assessed.

Results: In DSP patients, the number of PC in the forefoot was significantly reduced compared to healthy volunteers (82.7 ± 46.1 vs. 265.3 ± 49.3, p < 0.001). In contrast to the typical "chain-like" pattern of PC in healthy volunteers, their arrangement was heterogeneous in DSP patients and showed a more isolated "spot-like" pattern. Volunteers exhibited the highest PC number along the proximal phalanges, followed by the metatarsophalangeal (MTP) joints, while in patients, no such predominance was found. In DSP patients, the maximum diameter of PC was 3 mm (range 1-3 mm) compared to 5 mm (1-5 mm) in healthy volunteers. In patients, the mean duration of diabetes was 234.8 ± 130.4 months, and the mean HbA1c was 7.6 ± 1.1%. There was no significant correlation between PC number, duration of diabetes, and HbA1c.

Conclusion: DSP patients had threefold lower PC numbers in the forefoot and exhibited a "spot-like" PC distribution pattern rather than the typical "chain-like" pattern observed in healthy volunteers. The exact depiction of PC and their distribution in the forefoot opens up the possibility of using MRI as a noninvasive diagnostic tool to assess DSP.

Critical relevance statement: MRI may serve as a noninvasive diagnostic tool for assessing patients with diabetic sensorimotor polyneuropathy as it allows for evaluating Pacinian corpuscle number and distribution in the forefoot.

Key points: DSP patients showed three times lower forefoot PC numbers than healthy volunteers. PC distribution was altered in DSP patients and termed a "spot-like" pattern. Reduced PC (n < 9 along each MTP joint II-V) might be suspicious for DSP.

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糖尿病感觉运动多发性神经病前足Pacinian小体数量及分布的MRI评价。

目的：用MRI评价2型糖尿病源性感觉运动多神经病变（DSP）患者前足Pacinian小体（PC）的变化。材料和方法：本单中心研究比较了20例接受临床前足3-T MRI检查的DSP患者与年龄和性别相匹配的健康志愿者。两名放射科医生独立评估了PC的数量和分布。另外，一位放射科医生确定了PC的大小。评估PC数、糖尿病病程和糖化血红蛋白（HbA1c）之间的相关性。结果：DSP患者的前足PC数量明显少于健康志愿者（82.7±46.1比265.3±49.3,p）。结论：DSP患者的前足PC数量比健康志愿者低3倍，且呈现“点状”PC分布模式，而不是健康志愿者典型的“链状”PC分布模式。PC的准确描述及其在前足的分布开辟了使用MRI作为评估DSP的非侵入性诊断工具的可能性。关键相关性声明：MRI可以作为评估糖尿病感觉运动多神经病变患者的无创诊断工具，因为它可以评估前足的太平洋小体数量和分布。重点：DSP患者的前足PC数比健康志愿者低3倍。在DSP患者中，PC分布发生改变，并被称为“点样”模式。降低PC (n)

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来源期刊

Insights into Imaging Medicine-Radiology, Nuclear Medicine and Imaging

CiteScore

7.30

自引率

4.30%

发文量

182

审稿时长

13 weeks

期刊介绍： Insights into Imaging (I³) is a peer-reviewed open access journal published under the brand SpringerOpen. All content published in the journal is freely available online to anyone, anywhere! I³ continuously updates scientific knowledge and progress in best-practice standards in radiology through the publication of original articles and state-of-the-art reviews and opinions, along with recommendations and statements from the leading radiological societies in Europe. Founded by the European Society of Radiology (ESR), I³ creates a platform for educational material, guidelines and recommendations, and a forum for topics of controversy. A balanced combination of review articles, original papers, short communications from European radiological congresses and information on society matters makes I³ an indispensable source for current information in this field. I³ is owned by the ESR, however authors retain copyright to their article according to the Creative Commons Attribution License (see Copyright and License Agreement). All articles can be read, redistributed and reused for free, as long as the author of the original work is cited properly. The open access fees (article-processing charges) for this journal are kindly sponsored by ESR for all Members. The journal went open access in 2012, which means that all articles published since then are freely available online.