The Effect of Maternal Antioxidant Vitamin Supplementation on Maternal and Cord Blood Adiponectin Concentrations.

IF 1.2 4区 医学 Q3 OBSTETRICS & GYNECOLOGY
American journal of perinatology Pub Date : 2025-08-01 Epub Date: 2025-03-06 DOI:10.1055/a-2509-1828
Jessica L Pippen, Paula McGee, James M Roberts, Leslie Myatt, Michael W Varner, Alan T N Tita, Ronald J Wapner, John M Thorp, Brian M Mercer, Beth A Plunkett, Sean C Blackwell, Anthony Sciscione, George R Saade
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引用次数: 0

Abstract

Adiponectin is a hormone that modulates glucose regulation and fatty acid oxidation. Low adiponectin concentration has been associated with increased insulin resistance. Studies show a beneficial effect of vitamin E supplementation on insulin sensitivity. We aimed to investigate the association of prenatal antioxidant supplementation with increased adiponectin concentrations in pregnant participants and their newborn infants.Secondary analysis of a randomized control trial of prenatal vitamin C and E supplementation to prevent preeclampsia in low-risk nulliparous participants. Plasma of participants at time of randomization (9-16 weeks gestation) and delivery, and neonatal cord blood were analyzed by specific enzyme-linked immunosorbent assay for adiponectin concentration. Multivariable analysis was adjusted for confounders.A total of 198 (98 vitamin, 100 placebo) maternal-neonatal dyad samples were analyzed. Maternal and neonatal characteristics were similar between the vitamin and placebo groups, with the exception of race/ethnicity, with Whites more common in the placebo group (80 vs. 66.3%, p = 0.02). In bivariable analyses, adiponectin concentrations at delivery were higher in the vitamin group compared with the placebo group (29.4 vs. 27.5 µg/mL, p = 0.04), whereas cord blood adiponectin concentrations were similar (26.6 . vs. 27.4 µg/mL, p = 0.47) between the two groups. There was a significant interaction between treatment group and maternal baseline adiponectin level on the adiponectin concentrations at delivery (p = 0.04) and cord blood adiponectin (p < 0.05). For participants whose baseline adiponectin concentrations were in the highest tertile, vitamin supplementation was associated with higher adiponectin concentrations at delivery. However, for participants whose baseline adiponectin concentration were in the lowest tertile, vitamin supplementation was associated with lower cord blood adiponectin concentrations.For participants with high baseline adiponectin concentration, vitamin C and E supplementation is associated with higher adiponectin concentration at delivery. Conversely, vitamin supplementation is associated with lower cord adiponectin concentration among participants with low baseline adiponectin concentration. · Vitamin E is an antioxidant with metabolic properties.. · Adiponectin is a cytokine with metabolic properties.. · Vitamin E is associated with higher pregnancy adiponectin.. · Vitamin E is associated with lower neonatal adiponectin.. · Vitamin E correlated with positive pregnancy and neonatal adiponectin trends..

母体抗氧化维生素补充对母体和脐带血脂联素浓度的影响。
脂联素是一种调节葡萄糖调节和脂肪酸氧化的激素。低脂联素浓度与胰岛素抵抗增加有关。研究表明补充维生素E对胰岛素敏感性有好处。我们的目的是研究产前抗氧化剂补充与孕妇及其新生儿脂联素浓度增加的关系。一项随机对照试验的二次分析产前维生素C和E补充预防先兆子痫在低风险未分娩的参与者。随机分组时(妊娠9-16周)和分娩时的血浆以及新生儿脐带血采用特异性酶联免疫吸附法检测脂联素浓度。对多变量分析进行混杂因素校正。共分析了198例(98例维生素,100例安慰剂)母婴双体样本。孕妇和新生儿的特征在维生素组和安慰剂组之间相似,除了种族/民族之外,安慰剂组中白人更常见(80比66.3%,p = 0.02)。在双变量分析中,与安慰剂组相比,维生素组在分娩时的脂联素浓度更高(29.4 vs. 27.5µg/mL, p = 0.04),而脐带血脂联素浓度相似(26.6µg/mL)。vs. 27.4µg/mL, p = 0.47)。治疗组与产妇基线脂联素水平对分娩时脂联素浓度(p = 0.04)和脐带血脂联素(p = 0.04)有显著的相互作用
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来源期刊
American journal of perinatology
American journal of perinatology 医学-妇产科学
CiteScore
5.90
自引率
0.00%
发文量
302
审稿时长
4-8 weeks
期刊介绍: The American Journal of Perinatology is an international, peer-reviewed, and indexed journal publishing 14 issues a year dealing with original research and topical reviews. It is the definitive forum for specialists in obstetrics, neonatology, perinatology, and maternal/fetal medicine, with emphasis on bridging the different fields. The focus is primarily on clinical and translational research, clinical and technical advances in diagnosis, monitoring, and treatment as well as evidence-based reviews. Topics of interest include epidemiology, diagnosis, prevention, and management of maternal, fetal, and neonatal diseases. Manuscripts on new technology, NICU set-ups, and nursing topics are published to provide a broad survey of important issues in this field. All articles undergo rigorous peer review, with web-based submission, expedited turn-around, and availability of electronic publication. The American Journal of Perinatology is accompanied by AJP Reports - an Open Access journal for case reports in neonatology and maternal/fetal medicine.
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