Mental fatigue and cognitive functioning in patients presenting with non-enhancing gliomas

IF 1.9 3区医学 Q3 CLINICAL NEUROLOGY

Acta Neurochirurgica Pub Date : 2025-03-08 DOI:10.1007/s00701-025-06434-6

Alice Neimantaite, Tomás Gómez Vecchio, Isabelle Rydén, Dima Harba, Asgeir S. Jakola, Anja Smits

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引用次数: 0

Abstract

Purpose

Patients with diffuse lower-grade gliomas (LGG) often suffer from mental fatigue. In healthy subjects, mental fatigue has a negative impact on cognitive functioning. This relation may be more complex in LGG, where tumor localization and growth rate also impact brain function. Our aim was to investigate how self- and observer-reported variables of mental fatigue and cognitive functioning were connected before tumor treatment.

Methods

Consecutive patients scheduled for surgery due to presumed LGG were screened (n = 157). LGG was presumed if the mass was suggestive of diffuse glioma, but without significant contrast enhancement. Isocitrate dehydrogenase (IDH)-mutated WHO grade 2 or 3 gliomas (the LGG group) were analyzed separately. We included 101 patients in the entire cohort, whereas 71 patients constituted the LGG group. Patient data included: (1) self-reported assessments of mental fatigue and cognitive functioning, (2) neuropsychological test performances, and (3) clinical/demographic characteristics. Spearman's partial correlations were calculated between the variables and visualized in a correlation network.

Results

Cognitive impairment was self-reported by 50% of the entire cohort and 45% of the LGG group, while observer-evaluated testing showed cognitive impairment in 40% and 34% of the cases respectively. Self-reported assessments showed no correlations (≥ 0.3 or ≤-0.3) with neuropsychological test performances. A consistent correlation was seen between self-reported mental fatigue and self-reported cognitive functioning (entire cohort: rho=-0.66, LGG group: -0.64).

Conclusion

Our results highlight the complexity of evaluating symptoms of mental fatigue and cognitive functioning even prior to surgery. Self-reports and neuropsychological testing were weakly correlated, hence these should be handled complimentary.

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目的弥漫性低级别胶质瘤（LGG）患者经常感到精神疲劳。在健康人中，精神疲劳对认知功能有负面影响。这种关系在 LGG 中可能更为复杂，因为肿瘤的定位和生长速度也会影响大脑功能。我们的目的是调查自我和观察者报告的精神疲劳变量与认知功能在肿瘤治疗前的联系。如果肿块提示为弥漫性胶质瘤，但无明显对比度增强，则推测为 LGG。异柠檬酸脱氢酶（IDH）突变的WHO 2级或3级胶质瘤（LGG组）单独进行分析。我们将 101 名患者纳入整个队列，其中 71 名患者构成 LGG 组。患者数据包括(1) 自我报告的精神疲劳和认知功能评估；(2) 神经心理学测试表现；(3) 临床/人口学特征。计算了变量之间的斯皮尔曼偏相关，并在相关网络中进行了可视化。结果50%的患者和45%的LGG组患者自我报告了认知功能障碍，而观察者评估测试显示分别有40%和34%的病例存在认知功能障碍。自我报告的评估结果与神经心理学测试结果没有相关性（≥ 0.3 或≤-0.3）。自我报告的精神疲劳与自我报告的认知功能之间存在一致的相关性（整个队列：rho=-0.66，LGG 组：-0.64）。自我报告和神经心理学测试之间的相关性很弱，因此应该同时进行。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Neurochirurgica 医学-临床神经学

CiteScore

4.40

自引率

4.20%

发文量

342

审稿时长

1 months

期刊介绍： The journal "Acta Neurochirurgica" publishes only original papers useful both to research and clinical work. Papers should deal with clinical neurosurgery - diagnosis and diagnostic techniques, operative surgery and results, postoperative treatment - or with research work in neuroscience if the underlying questions or the results are of neurosurgical interest. Reports on congresses are given in brief accounts. As official organ of the European Association of Neurosurgical Societies the journal publishes all announcements of the E.A.N.S. and reports on the activities of its member societies. Only contributions written in English will be accepted.