Sodium azide (NaN3) intoxication, “the man who lived”: potential effective antidote and treatment strategy

IF 8.8 1区医学 Q1 CRITICAL CARE MEDICINE

Critical Care Pub Date : 2025-03-07 DOI:10.1186/s13054-025-05330-w

Jasper X. Geerdink, Greetje van der Wal, Lutea A. A. de Jong, Erik J. H. Olyslager, Thomas W. van den Goorbergh, Leo A. J. Kluijtmans, Peter E. Spronk

引用次数: 0

Abstract

This case report describes the successful treatment of a suicide attempt involving the ingestion of a supralethal dose of sodium azide (NaN3), presenting a prospective novel antidote and therapeutic approach. Treatment encompassed the implementation of high-volume continuous veno-venous hemofiltration (HV-CVVH) alongside the administration of levocarnitine. The latter demonstrated a substantial mitigation of lactate concentration. Comprehensive analyses of serum, ultrafiltrate, and urine revealed the efficacy of HV-CVVH in elimination of NaN3. Our case report presents a potential therapeutic approach for managing otherwise fatal NaN3 intoxications.

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叠氮化钠（NaN3）中毒，“活的人”：潜在有效解药及治疗策略

本病例报告描述了成功治疗自杀未遂涉及摄入超致死剂量叠氮化钠（NaN3），提出了一种前瞻性的新型解毒剂和治疗方法。治疗包括实施大容量连续静脉-静脉血液滤过（HV-CVVH），同时给予左卡尼汀。后者显示出乳酸浓度的显著降低。血清、超滤液和尿液的综合分析显示了HV-CVVH在消除NaN3方面的有效性。我们的病例报告提出了一种潜在的治疗方法来管理否则致命的NaN3中毒。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Critical Care 医学-危重病医学

CiteScore

20.60

自引率

3.30%

发文量

348

审稿时长

1.5 months

期刊介绍： Critical Care is an esteemed international medical journal that undergoes a rigorous peer-review process to maintain its high quality standards. Its primary objective is to enhance the healthcare services offered to critically ill patients. To achieve this, the journal focuses on gathering, exchanging, disseminating, and endorsing evidence-based information that is highly relevant to intensivists. By doing so, Critical Care seeks to provide a thorough and inclusive examination of the intensive care field.