Tranexamic acid in elective pediatric orthopedic surgery: a comprehensive review.

IF 0.9 4区 医学 Q4 ORTHOPEDICS
Gina Ledesma Negreiros, Dalmiro Zúñiga Baca, José Caballero-Alvarado, Carlos Zavaleta-Corvera
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引用次数: 0

Abstract

Tranexamic acid (TXA), approved initially for medical bleeding, has expanded its utility to various surgical contexts, including pediatric orthopedic and trauma surgery, though limited research has been conducted in this population. This study aimed to evaluate TXA's efficacy and safety in pediatric orthopedic and trauma surgeries, focusing on its impact on blood loss reduction and transfusion requirements. Through a comprehensive literature review following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, eight retrospective studies were analyzed, all involving pediatric patients with cerebral palsy undergoing orthopedic surgery. TXA dosing regimens varied across studies, with loading doses ranging from 10 to 50 mg/kg and maintenance doses from 1 to 10 mg/kg/h. Consistently, TXA administration was associated with a significant decrease in intraoperative blood loss and transfusion needs compared with nonadministered groups, with no reported thromboembolic events, indicating its safety in pediatric orthopedic and trauma surgeries.

氨甲环酸在选择性小儿骨科手术中的应用综述。
氨甲环酸(TXA)最初被批准用于治疗内科出血,现已将其应用范围扩大到各种外科情况,包括儿科骨科和创伤外科,尽管在这一人群中进行的研究有限。本研究旨在评估TXA在儿科骨科和创伤手术中的有效性和安全性,重点关注其对减少失血量和输血需求的影响。根据系统评价和荟萃分析指南的首选报告项目,通过全面的文献综述,分析了8项回顾性研究,所有研究均涉及接受骨科手术的脑瘫儿童患者。TXA给药方案因研究而异,负荷剂量为10 - 50mg /kg,维持剂量为1 - 10mg /kg/h。一致地,与未给药组相比,给药TXA与术中出血量和输血需求的显著减少有关,没有血栓栓塞事件的报道,表明其在儿科骨科和创伤手术中的安全性。
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来源期刊
CiteScore
2.20
自引率
9.10%
发文量
170
审稿时长
4-8 weeks
期刊介绍: The journal highlights important recent developments from the world''s leading clinical and research institutions. The journal publishes peer-reviewed papers on the diagnosis and treatment of pediatric orthopedic disorders. It is the official journal of IFPOS (International Federation of Paediatric Orthopaedic Societies). Submitted articles undergo a preliminary review by the editor. Some articles may be returned to authors without further consideration. Those being considered for publication will undergo further assessment and peer-review by the editors and those invited to do so from a reviewer pool. ​
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