The first human study of add-on PET: A PET-integrated RF coil for 3 T MRI.

IF 3 2区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

EJNMMI Physics Pub Date : 2025-03-06 DOI:10.1186/s40658-025-00731-w

Miwako Takahashi, Fumihiko Nishikido, Go Akamatsu, Hideaki Tashima, Yuma Iwao, Mikio Suga, Taiga Yamaya

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引用次数: 0

Abstract

Background: Combined PET and MRI scanners allow for simultaneous image acquisition, simplifying the interpretation of both PET and MRI images. We prototyped an insert-type PET that can convert a standalone MRI to a PET-MRI system, named Add-on PET. In Add-on PET, we fully integrated the PET modules into a head radiofrequency (RF) coil so that PET detectors can be close to the brain and avoid placing the RF coil in the field of view of PET. This study aimed at confirming the feasibility of human brain simultaneous PET and MRI imaging using a prototype of add-on PET.

Results: The PET images obtained with and without simultaneous MRI sequences were identical (Pearson's correlation coefficient, r = 0.953). Background noise was observed in the MRI images acquired during the PET scan; however, the noise decreased when the count rates of PET declined. The MRI obtained simultaneously was used for attenuation correction, providing well-correlated voxel values with those using the CT-based attenuation correction method (r = 0.989).

Conclusions: The simultaneous PET and MRI images were performed without noticeable artifacts. There was no significant interference in PET images caused by the simultaneous MRI sequence; however, some background noise was observed in the MRI, likely due to the electric current from PET modules used for counting a clinically used radioactivity concentration.

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背景：正电子发射计算机断层显像（PET）和核磁共振成像（MRI）联合扫描仪可同时采集图像，从而简化了正电子发射计算机断层显像和核磁共振成像的判读。我们开发了一种插入式正电子发射计算机原型，可将独立的核磁共振成像系统转换为正电子发射计算机-核磁共振成像系统，命名为附加正电子发射计算机。在Add-on PET中，我们将PET模块完全集成到头部射频线圈中，这样PET探测器就可以靠近大脑，避免将射频线圈置于PET的视野中。这项研究旨在利用附加 PET 的原型确认人脑同步 PET 和 MRI 成像的可行性：使用和不使用同步核磁共振成像序列获得的 PET 图像完全相同（皮尔逊相关系数 r = 0.953）。在 PET 扫描期间获得的 MRI 图像中出现了背景噪声；然而，当 PET 的计数率下降时，噪声也随之下降。同时获得的 MRI 用于衰减校正，提供的体素值与使用基于 CT 的衰减校正方法的体素值相关性良好（r = 0.989）：结论：同步 PET 和 MRI 图像处理无明显伪影。同步磁共振成像序列对正电子发射计算机断层显像没有造成明显干扰；但在磁共振成像中观察到了一些背景噪声，这可能是由于正电子发射计算机断层显像模块用于计算临床使用的放射性浓度的电流造成的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

EJNMMI Physics Physics and Astronomy-Radiation

CiteScore

6.70

自引率

10.00%

发文量

审稿时长

13 weeks

期刊介绍： EJNMMI Physics is an international platform for scientists, users and adopters of nuclear medicine with a particular interest in physics matters. As a companion journal to the European Journal of Nuclear Medicine and Molecular Imaging, this journal has a multi-disciplinary approach and welcomes original materials and studies with a focus on applied physics and mathematics as well as imaging systems engineering and prototyping in nuclear medicine. This includes physics-driven approaches or algorithms supported by physics that foster early clinical adoption of nuclear medicine imaging and therapy.