Weight-adjusted waist circumference index with hepatic steatosis and fibrosis in adult females: a cross-sectional, nationally representative study (NHANES 2017-2020).

IF 2.5 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY
Yu-E Lian, Yixuan Wang, Yinyin Yang, Jiayu Chen
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引用次数: 0

Abstract

Background: Obesity is detrimental to liver health. Weight-adjusted waist circumference (WWI) is a new indicator of obesity that is superior to body mass index (BMI) and waist circumference (WC) in predicting obesity. There are limited studies on the relationship between Metabolic Associated Fatty Liver Disease (MASLD) and WWI. Therefore, this study aimed to investigate the association between WWI, Controlled Attenuation Parameters (CAP), and Liver Stiffness Measurement (LSM), with special attention to gender differences.

Methods: This cross-sectional study included participants from the 2017 to 2020 National Health and Nutrition Examination Survey (NHANES). The study used multiple linear regression models, smoothed curves, and threshold effects analyses to describe the relationships between variables. Multiple regression analyses were used to examine the associations between the four obesity indicators and CAP and LSM. Subject work characteristics (ROC) curves were used to assess the predictive value of WWI and other traditional obesity indicators for hepatic steatosis and liver fibrosis, and predictive power was assessed by area under the curve (AUC).

Results: The study involved 6713 participants, including 3072 men (46%) and 3641 women (54%). The results showed that among female participants, higher WWI was associated with hepatic steatosis (OR = 1.71, 95% CI: 1.43, 2.04; P < 0.0001) and hepatic fibrosis (OR = 2.11, 95% CI: 1.58, 2.84; P < 0.0001). Smoothed curve fitting of WWI versus CAP showed a statistically significant positive correlation between WWI in male and female participants There was a statistically significant positive correlation with CAP for both male and female participants. The same significant non-linear relationship was found between WWI and LSM, with no significant difference between males and females. WWI was also a good predictor of hepatic steatosis compared to other obesity indicators and was more pronounced in male participants (AUC = 0.8224). Whereas in the comparison of WWI with LSM, wBMI was a better predictor in female participants (AUC = 0.7751).

Conclusions: Based on this study, WWI was significantly associated with the risk of hepatic steatosis and hepatic fibrosis in women, suggesting the potential of WWI as a screening tool. Due to the cross-sectional design, causality cannot be inferred. Longitudinal studies are needed to validate our findings.

体重调整腰围指数与成年女性肝脂肪变性和纤维化的关系:一项全国代表性的横断面研究(NHANES 2017-2020)。
背景:肥胖对肝脏健康有害。体重调整腰围(WWI)是一种新的肥胖指标,在预测肥胖方面优于体重指数(BMI)和腰围(WC)。关于代谢性脂肪性肝病(MASLD)与一战之间关系的研究有限。因此,本研究旨在探讨WWI、控制衰减参数(CAP)和肝脏刚度测量(LSM)之间的关系,并特别关注性别差异。方法:本横断面研究纳入了2017年至2020年国家健康与营养检查调查(NHANES)的参与者。本研究采用多元线性回归模型、平滑曲线和阈值效应分析来描述变量之间的关系。采用多元回归分析检验4项肥胖指标与CAP和LSM之间的关系。采用受试者工作特征(ROC)曲线评估WWI等传统肥胖指标对肝脂肪变性和肝纤维化的预测价值,并通过曲线下面积(AUC)评估预测能力。结果:该研究涉及6713名参与者,包括3072名男性(46%)和3641名女性(54%)。结果显示,在女性受试者中,较高的WWI与肝脏脂肪变性相关(OR = 1.71, 95% CI: 1.43, 2.04;结论:基于本研究,WWI与女性肝脂肪变性和肝纤维化风险显著相关,提示WWI可能作为筛查工具。由于横断面设计,不能推断因果关系。需要进行纵向研究来验证我们的发现。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
BMC Gastroenterology
BMC Gastroenterology 医学-胃肠肝病学
CiteScore
4.20
自引率
0.00%
发文量
465
审稿时长
6 months
期刊介绍: BMC Gastroenterology is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of gastrointestinal and hepatobiliary disorders, as well as related molecular genetics, pathophysiology, and epidemiology.
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