Predictors for Upgrade to Breast Cancer in Patients with B3 Lesions Diagnosed by Core Biopsy: A Retrospective Cohort Study.

IF 2 4区 医学 Q2 OBSTETRICS & GYNECOLOGY
Breast Care Pub Date : 2025-03-03 Epub Date: 2024-11-11 DOI:10.1159/000542551
Burak Dinçer, Ceylan Yanar, Ramazan Uçak, Esma Çerekçi, Cemal Kaya
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引用次数: 0

Abstract

Background: The optimal approach to B3 lesions is controversial, and the risk of malignant upgrade varies between studies. This study aimed to evaluate the factors affecting the risk of upgrading to breast cancer in patients diagnosed with B3 lesions by core biopsy.

Methods: A total of 410 patients diagnosed with B3 lesions by core biopsy and subsequently undergoing surgical excision were evaluated. Patients who did not undergo surgical excision or were not followed up at our center were excluded. Patients were analyzed based on demographic, clinical, radiological, and pathological findings.

Results: All 410 patients included in the study were women, with a median age of 47 years (range 21-78). An upgrade to in situ or invasive disease was observed in 117 of the 410 patients (28.5%). In univariate analysis, age, mammographic findings, histopathological type, and atypia in core biopsy were identified as significant factors affecting the upgrade rate (p = 0.046, p = 0.028, p < 0.001, and p < 0.001, respectively). In multivariate analysis, the presence of atypia (p < 0.001) and a diagnosis of atypical ductal hyperplasia (ADH) (p = 0.026) were determined to be independent variables that increase the upgrade rate.

Conclusion: Surgical excision or vacuum-assisted excision may be more appropriate for ADH and B3 lesions with atypia on core biopsy.

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来源期刊
Breast Care
Breast Care 医学-妇产科学
CiteScore
4.40
自引率
4.80%
发文量
45
审稿时长
6-12 weeks
期刊介绍: ''Breast Care'' is a peer-reviewed scientific journal that covers all aspects of breast biology. Due to its interdisciplinary perspective, it encompasses articles on basic research, prevention, diagnosis, and treatment of malignant diseases of the breast. In addition to presenting current developments in clinical research, the scope of clinical practice is broadened by including articles on relevant legal, financial and economic issues.
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