Predictors for Upgrade to Breast Cancer in Patients with B3 Lesions Diagnosed by Core Biopsy: A Retrospective Cohort Study.

IF 2 4区医学 Q2 OBSTETRICS & GYNECOLOGY

Breast Care Pub Date : 2025-03-03 Epub Date: 2024-11-11 DOI:10.1159/000542551

Burak Dinçer, Ceylan Yanar, Ramazan Uçak, Esma Çerekçi, Cemal Kaya

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引用次数: 0

Abstract

Background: The optimal approach to B3 lesions is controversial, and the risk of malignant upgrade varies between studies. This study aimed to evaluate the factors affecting the risk of upgrading to breast cancer in patients diagnosed with B3 lesions by core biopsy.

Methods: A total of 410 patients diagnosed with B3 lesions by core biopsy and subsequently undergoing surgical excision were evaluated. Patients who did not undergo surgical excision or were not followed up at our center were excluded. Patients were analyzed based on demographic, clinical, radiological, and pathological findings.

Results: All 410 patients included in the study were women, with a median age of 47 years (range 21-78). An upgrade to in situ or invasive disease was observed in 117 of the 410 patients (28.5%). In univariate analysis, age, mammographic findings, histopathological type, and atypia in core biopsy were identified as significant factors affecting the upgrade rate (p = 0.046, p = 0.028, p < 0.001, and p < 0.001, respectively). In multivariate analysis, the presence of atypia (p < 0.001) and a diagnosis of atypical ductal hyperplasia (ADH) (p = 0.026) were determined to be independent variables that increase the upgrade rate.

Conclusion: Surgical excision or vacuum-assisted excision may be more appropriate for ADH and B3 lesions with atypia on core biopsy.

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核心活检诊断为B3病变的患者升级为乳腺癌的预测因素：一项回顾性队列研究。

背景：B3病变的最佳入路存在争议，不同研究间恶性升级的风险不同。本研究旨在评价影响核心活检诊断为B3病变的患者升级为乳腺癌风险的因素。方法：对410例经核心活检诊断为B3病变并行手术切除的患者进行评估。未接受手术切除或未在本中心随访的患者被排除在外。根据人口统计学、临床、放射学和病理结果对患者进行分析。结果：纳入研究的410例患者均为女性，中位年龄为47岁（21-78岁）。410例患者中有117例（28.5%）升级为原位或侵袭性疾病。在单因素分析中，年龄、乳房x光检查结果、组织病理类型和核心活检的非典型性被确定为影响升级率的重要因素（p = 0.046、p = 0.028、p < 0.001和p < 0.001）。在多变量分析中，异型性的存在（p < 0.001）和非典型导管增生（ADH）的诊断（p = 0.026）被确定为增加升级率的独立变量。结论：ADH和B3型核心活检有异型性的病变，手术切除或真空辅助切除更为合适。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Breast Care 医学-妇产科学

CiteScore

4.40

自引率

4.80%

发文量

审稿时长

6-12 weeks

期刊介绍： ''Breast Care'' is a peer-reviewed scientific journal that covers all aspects of breast biology. Due to its interdisciplinary perspective, it encompasses articles on basic research, prevention, diagnosis, and treatment of malignant diseases of the breast. In addition to presenting current developments in clinical research, the scope of clinical practice is broadened by including articles on relevant legal, financial and economic issues.