Scoping literature review to identify candidate domains for the OMERACT Systemic Lupus Erythematosus core outcome set

IF 4.6 2区医学 Q1 RHEUMATOLOGY

Seminars in arthritis and rheumatism Pub Date : 2025-02-27 DOI:10.1016/j.semarthrit.2025.152684

Wils Nielsen , Fadi Kharouf , Carolina Munoz Grajales , Aarabi Thayaparan , Melanie Anderson , Vibeke Strand , Lee Simon , Dennisse Bonilla , Eric Morand , Julian Thumboo , Martin Aringer , Marta Mosca , Ian Bruce , Elektra J. Papadopoulos , Karina D. Torralba , Laura Patricia Whitall-Garcia , Cheryl F. Rosen , Ioannis Parodis , Alfred Kim , Maya Desai , Zahi Touma

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Abstract

Objective

To identify candidate Systemic Lupus Erythematosus (SLE) domains from the literature for consideration towards the development of the SLE Core Outcome Set.

Methods

This was a comprehensive scoping literature review of SLE clinical trials and systematic reviews published since 2010. Studies were identified from 5 databases and were screened for eligibility. Candidate domains were extracted from the included studies. Candidate domains were winnowed and binned by the Outcome Measures in Rheumatology (OMERACT) SLE Advisory Group.

Results

Of the 4063 studies identified, 507 met inclusion criteria and proceeded to data extraction. Multiple domains and items were extracted, which winnowing and binning reduced to 25 candidate domains.

Conclusion

The 25 candidate domains cover the important aspects of SLE and the 4 core areas of disease impact according to OMERACT framework. The 25 candidate domains constitute a feasible and manageable number of domains to proceed with to the core domain consensus stage that covers the wide range of impact of SLE. The candidate domains will be supplemented by ongoing qualitative research with patients living with SLE to identify additional domains before proceeding to the consensus stage.

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范围的文献回顾，以确定候选域的OMERACT系统性红斑狼疮核心结局集

目的从文献中确定系统性红斑狼疮（SLE）的候选域，以考虑SLE核心结局集的发展。方法：对2010年以来发表的系统性红斑狼疮临床试验和系统评价进行全面的文献综述。从5个数据库中确定研究，并对其进行资格筛选。从纳入的研究中提取候选域。候选领域通过风湿病预后测量（OMERACT） SLE咨询小组进行筛选和分类。在4063项研究中，507项符合纳入标准，并进行了数据提取。提取多个域和项，经过筛选和分箱处理，减少到25个候选域。结论根据OMERACT框架，25个候选域涵盖SLE的重要方面和疾病影响的4个核心领域。这25个候选领域构成了一个可行和可管理的领域数量，可以继续进行核心领域共识阶段，该阶段涵盖SLE的广泛影响。在进入共识阶段之前，候选领域将通过对SLE患者进行的定性研究来补充，以确定其他领域。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Seminars in arthritis and rheumatism 医学-风湿病学

CiteScore

9.20

自引率

4.00%

发文量

176

审稿时长

46 days

期刊介绍： Seminars in Arthritis and Rheumatism provides access to the highest-quality clinical, therapeutic and translational research about arthritis, rheumatology and musculoskeletal disorders that affect the joints and connective tissue. Each bimonthly issue includes articles giving you the latest diagnostic criteria, consensus statements, systematic reviews and meta-analyses as well as clinical and translational research studies. Read this journal for the latest groundbreaking research and to gain insights from scientists and clinicians on the management and treatment of musculoskeletal and autoimmune rheumatologic diseases. The journal is of interest to rheumatologists, orthopedic surgeons, internal medicine physicians, immunologists and specialists in bone and mineral metabolism.