Cobalt(II) complexes of tri-dentate S,N,S-thiophenyl Schiff base ligand for prospective biological studies and ct-DNA interaction. Catalytic benzyl alcohol oxidative performance

IF 5.3 2区化学 Q2 CHEMISTRY, PHYSICAL

Journal of Molecular Liquids Pub Date : 2025-03-03 DOI:10.1016/j.molliq.2025.127269

Zakaria S. Bakhuraisa , Ahmed Khalil , Mustafa J. Abdelmageed Abualreish , Ahmed Desoky M. Mohamad , Mamdouh A. Mohamed , Mohamed Shaker S. Adam

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Abstract

The condensing reaction of thiophene-2-carbaldehyde with 2-aminobenzenethiol yielded S,N,S-thiophenyl Schiff base ligand (HLNS). In various molar ratios, the coordination behavior of HLNS towards cobalt(II) ions was studied within 1 and 2: 1 equivalents, resulting in the formation of two diverse structural complexes, [CoLNSCl(H₂O)₂] and [Co(LNS)₂], respectively. Their structural elucidation was achieved using various spectroscopic methods, which involved thermogravimetric assessments, elemental analysis, magnetic characteristics, and conductivity measurements.

The inhibitory influence of HLNS (as an unbonded ligand) and its cobalt(II)-chelating agents on the restrained proliferation of three particular microbes of bacterial and fungal strains, and three recognized cell lines of human cancer were assessed assigning the structural effect on the reactivity of [CoLNSCl(H₂O)₂] and [Co(LNS)₂] versus their free ligand (HLNS). The study sought to ascertain the predominant role of Co(II) ions in the two chelates on the binding strength of HLNS, [CoLNSCl(H₂O)₂], and [Co(LNS)₂] towards calf thymus DNA (ct-DNA), which was evaluated by examining the changes in their viscometric and spectrophotometric characteristics. The evaluation of binding constants (K_b), Gibbs free energy

Δ G_{b}^{\neq}

, and chromism modes was utilized to analyze the interaction modes of the current compounds with ct-DNA compared to that action of HLNS.

[CoLNSCl(H₂O)₂] and [Co(LNS)₂] represented high catalytic oxidative performance for benzyl alcohol with hydrogen peroxide homogeneously. At 80 °C, the yielding percentage of the selective-product (benzaldehyde) was 85 % after 4 h and 82 % after 5 h with [CoLNSCl(H₂O)₂] and [Co(LNS)₂], respectively. The variation in the optimal atmosphere for both catalysts referred to their molecular structure differences.

Abstract Image

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三齿 S,N,S-噻吩希夫碱配体的钴(II)配合物，用于前瞻性生物研究和 ct-DNA 相互作用。催化苯甲醇氧化性能

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来源期刊

Journal of Molecular Liquids 化学-物理：原子、分子和化学物理

CiteScore

10.30

自引率

16.70%

发文量

2597

审稿时长

78 days

期刊介绍： The journal includes papers in the following areas: – Simple organic liquids and mixtures – Ionic liquids – Surfactant solutions (including micelles and vesicles) and liquid interfaces – Colloidal solutions and nanoparticles – Thermotropic and lyotropic liquid crystals – Ferrofluids – Water, aqueous solutions and other hydrogen-bonded liquids – Lubricants, polymer solutions and melts – Molten metals and salts – Phase transitions and critical phenomena in liquids and confined fluids – Self assembly in complex liquids.– Biomolecules in solution The emphasis is on the molecular (or microscopic) understanding of particular liquids or liquid systems, especially concerning structure, dynamics and intermolecular forces. The experimental techniques used may include: – Conventional spectroscopy (mid-IR and far-IR, Raman, NMR, etc.) – Non-linear optics and time resolved spectroscopy (psec, fsec, asec, ISRS, etc.) – Light scattering (Rayleigh, Brillouin, PCS, etc.) – Dielectric relaxation – X-ray and neutron scattering and diffraction. Experimental studies, computer simulations (MD or MC) and analytical theory will be considered for publication; papers just reporting experimental results that do not contribute to the understanding of the fundamentals of molecular and ionic liquids will not be accepted. Only papers of a non-routine nature and advancing the field will be considered for publication.