Implementing the EURL ECVAM Recommendation on Non-Animal-Derived Antibodies in One EU Member State - Denmark.

IF 2.4 4区 医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL
Atla-Alternatives To Laboratory Animals Pub Date : 2025-03-01 Epub Date: 2025-03-04 DOI:10.1177/02611929251324520
Bente Lakjer, Rosemary Goddard Svendsen
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引用次数: 0

Abstract

In 2020, the EU Commission's Joint Research Centre published the EURL ECVAM Recommendation on Non-Animal-Derived Antibodies. In advance of the publication of this EURL ECVAM Recommendation, Landsforeningen Forsøgsdyrenes Værn arranged for an expert presentation on non-animal-derived antibodies to the Animal Experimentation Council, which is the body responsible for the review and approval of projects involving animals in Denmark. The main concerns of Council Members following the presentation were the widespread unfamiliarity with phage display methodology in Denmark, and how it would be possible to adapt licensing decisions. Before deciding how to approach the implementation of the Recommendation, the animal experimentation authority Dyreforsøgstilsynet, of which the Animal Experimentation Council and its secretariat are part, probed the wider scientific community and requested an opinion from the National Committee on Laboratory Animals and Alternatives. Wider scientific opinion in Denmark spanned those who were, to a certain extent, positive toward the non-animal methodology and those who were sceptical. Consequently, the approach chosen by the Danish authority is to encourage and monitor the uptake of non-animal methods, while allowing time for adjustment. Change has been slow, but the seeds of change are sown.

在一个欧盟成员国——丹麦实施EURL ECVAM关于非动物源性抗体的建议。
2020年,欧盟委员会联合研究中心发布了EURL ECVAM关于非动物源性抗体的建议。在EURL ECVAM建议发布之前,Landsforeningen forsdyrenes Værn安排了一场关于非动物源性抗体的专家报告给动物实验委员会,该委员会是丹麦负责审查和批准涉及动物的项目的机构。理事会成员在介绍后的主要担忧是丹麦对噬菌体展示方法的普遍不熟悉,以及如何可能适应许可决定。在决定如何实施该建议之前,动物实验权威机构dyresforsgstilsynet(动物实验委员会及其秘书处都是该机构的一部分)调查了更广泛的科学界,并征求了国家实验动物和替代品委员会的意见。在丹麦,更广泛的科学观点包括在一定程度上对非动物方法持积极态度的人和持怀疑态度的人。因此,丹麦当局选择的方法是鼓励和监测非动物方法的采用,同时给予时间进行调整。变化缓慢,但变化的种子已经播下。
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来源期刊
CiteScore
3.80
自引率
3.70%
发文量
60
审稿时长
>18 weeks
期刊介绍: Alternatives to Laboratory Animals (ATLA) is a peer-reviewed journal, intended to cover all aspects of the development, validation, implementation and use of alternatives to laboratory animals in biomedical research and toxicity testing. In addition to the replacement of animals, it also covers work that aims to reduce the number of animals used and refine the in vivo experiments that are still carried out.
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