{"title":"Neuropsychiatric Abnormalities in Metabolic Disturbances: Interplay of Adipokines and Neurotransmission.","authors":"So Yeong Cheon, Juhyun Song","doi":"10.1007/s12035-025-04797-6","DOIUrl":null,"url":null,"abstract":"<p><p>Metabolic syndrome, with a high global incidence, is characterized by central obesity, elevated fasting blood glucose, high blood pressure, and abnormal lipid levels, including reduced high-density lipoprotein cholesterol and elevated triglycerides. These metabolic dysfunctions can lead to neurotransmitter alterations and dysregulation of the hypothalamic-pituitary-adrenal axis. These changes, in turn, contribute to mental disorders such as depression and anxiety. Adipokines, secreted from adipose tissue, modulate various metabolic processes, neurotransmission, and immune responses. The interplay between adipokines and neurotransmitters may be a critical component underlying the interaction between metabolic abnormalities and mental disorders. This review aims to discuss the brain-metabolism axis, focusing on altered levels of adipokines and neurotransmitters in metabolic and mental disorders.</p>","PeriodicalId":18762,"journal":{"name":"Molecular Neurobiology","volume":" ","pages":"8824-8842"},"PeriodicalIF":4.6000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Molecular Neurobiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s12035-025-04797-6","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/3/5 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
Metabolic syndrome, with a high global incidence, is characterized by central obesity, elevated fasting blood glucose, high blood pressure, and abnormal lipid levels, including reduced high-density lipoprotein cholesterol and elevated triglycerides. These metabolic dysfunctions can lead to neurotransmitter alterations and dysregulation of the hypothalamic-pituitary-adrenal axis. These changes, in turn, contribute to mental disorders such as depression and anxiety. Adipokines, secreted from adipose tissue, modulate various metabolic processes, neurotransmission, and immune responses. The interplay between adipokines and neurotransmitters may be a critical component underlying the interaction between metabolic abnormalities and mental disorders. This review aims to discuss the brain-metabolism axis, focusing on altered levels of adipokines and neurotransmitters in metabolic and mental disorders.
期刊介绍：
Molecular Neurobiology is an exciting journal for neuroscientists needing to stay in close touch with progress at the forefront of molecular brain research today. It is an especially important periodical for graduate students and "postdocs," specifically designed to synthesize and critically assess research trends for all neuroscientists hoping to stay active at the cutting edge of this dramatically developing area. This journal has proven to be crucial in departmental libraries, serving as essential reading for every committed neuroscientist who is striving to keep abreast of all rapid developments in a forefront field. Most recent significant advances in experimental and clinical neuroscience have been occurring at the molecular level. Until now, there has been no journal devoted to looking closely at this fragmented literature in a critical, coherent fashion. Each submission is thoroughly analyzed by scientists and clinicians internationally renowned for their special competence in the areas treated.
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