Evaluating Health-Related Quality of Life in Thalassemia: Low-Dose Thalidomide vs. Standard Care-Insights from a Comparative Study.

IF 1.2 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
Varsha Mishra, Pratibha Singh Yadav, Reema Singh, Sujay Rainchwar, Roy J Palatty, Tribikram Panda, Karuna Jha, Rohan Halder, Narendra Agrawal, Dinesh Bhurani
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Abstract

Thalassemia is a hemoglobinopathy that affects many people worldwide. Although treatments such as iron chelation and safe transfusions have improved life expectancy, patients still experience complications. Thalidomide, with its immunomodulatory and anti-angiogenic properties, has been found to increase the expression of the γ-globin gene and promote erythroid cell proliferation. Our study compared thalidomide-treated and standard therapy groups, assessing health-related quality of life in thalassemia patients using the SF-36 questionnaire tailored for the Indian population. A total of 84 patients (Thalidomide: 50, Standard: 34) were enrolled. Sixty-four percent of patients on thalidomide became transfusion-free within 4-6 months. The mean duration of transfusion requirement in the thalidomide group increased from 20 to 35 days in 30% of patients. Patients aged ≤ 20 years, without splenectomy, and unemployed had significantly better physical health component (PHC) scores with thalidomide therapy compared to standard therapy (P = 0.027, P = 0.0007, and P = 0.045, respectively). On the other hand, patients aged >20 years and with intact spleen had significantly better mental health component (MHC) scores with thalidomide therapy compared to standard therapy (P = 0.006 and P < 0.00001, respectively). Thalidomide therapy showed significantly better MHC scores than standard therapy on all four scales. Thalidomide therapy shows significant promise in improving the HRQoL for thalassemia patients, particularly in those with early initiation, as indicated by enhanced physical and mental health component scores and improved vitality, emotional well-being, role-emotional, and social functioning compared to standard care.

评估地中海贫血患者的健康相关生活质量:低剂量沙利度胺与标准护理——来自一项比较研究的见解
地中海贫血是一种影响全世界许多人的血红蛋白病。尽管铁螯合和安全输血等治疗方法改善了患者的预期寿命,但患者仍然会出现并发症。沙利度胺具有免疫调节和抗血管生成的特性,可增加γ-珠蛋白基因的表达,促进红细胞增殖。我们的研究比较了沙利度胺治疗组和标准治疗组,使用为印度人群量身定制的SF-36问卷评估地中海贫血患者的健康相关生活质量。共纳入84例患者(沙利度胺:50例,标准:34例)。64%使用沙利度胺的患者在4-6个月内不再输血。在30%的患者中,沙利度胺组的平均输血时间从20天增加到35天。年龄≤20岁、未行脾切除术、失业的患者,沙利度胺治疗的身体健康成分(PHC)评分明显优于标准治疗(P = 0.027、P = 0.0007、P = 0.045)。另一方面,年龄在bb0 ~ 20岁且脾脏完好的患者,沙利度胺治疗的心理健康成分(MHC)评分显著高于标准治疗(P = 0.006和P . 0.05)
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来源期刊
Hemoglobin
Hemoglobin 医学-生化与分子生物学
CiteScore
1.70
自引率
10.00%
发文量
59
审稿时长
3 months
期刊介绍: Hemoglobin is a journal in the English language for the communication of research and information concerning hemoglobin in humans and other species. Hemoglobin publishes articles, reviews, points of view The journal covers topics such as: structure, function, genetics and evolution of hemoglobins biochemical and biophysical properties of hemoglobin molecules characterization of hemoglobin disorders (variants and thalassemias), consequences and treatment of hemoglobin disorders epidemiology and prevention of hemoglobin disorders (neo-natal and adult screening) modulating factors methodology used for diagnosis of hemoglobin disorders
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