Viktoria Weixler, Peter Murin, Bana Samman, Julia Gaal, Alison Howell, Marcus Kelm, Peter Kramer, Chelsea Christie, Gloria Ho, Kyle Runeckles, Mimi Xiaoming Deng, Mi-Young Cho, David J Barron, Joachim Photiadis, Osami Honjo
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引用次数: 0
Abstract
Objectives: With 2 different Ross autograft implantation techniques: subcoronary versus full-root evolving, the question remains which strategy demonstrates the better early/mid-term performance, especially concerning autograft durability.
Methods: Patients (0-18 years) undergoing Ross procedure from January 2012 to December 2022 in 2 high-volume centres were included. Patients undergoing both subcoronary and full-root Ross were analysed for early mortality, direct postoperative complications, 5-year survival, incidence of reinterventions/reoperations and autograft durability over time. Propensity score matching and regression analysis were used to overcome institutional differences.
Results: A total of 205 paediatric patients were included [median age at Ross: 7.6 years (1.9-13.5), 67% males]. No differences in baseline characteristics were noted between the groups, except for prior aortic valve repair, which occurred more frequently in the full-root Ross (19% vs 6.9%; P = 0.03). Cardiopulmonary bypass durations (median 265 vs 221 min, P < 0.01), ventilatory support and hospital stay were significantly longer in the subcoronary Ross (P = 0.02) with no differences in any postoperative complications. No differences were noted in 5-year survival [full-root: 93.3% (87.5-96.5) versus subcoronary: 96.5% (86.6-99.1), P = 0.45], incidence of autograft reoperations [full-root: 3.2% (1-9.9) versus subcoronary: 2.1% (0.3-14.9), P = 0.98] or incidence of autograft regurgitation ≥ moderate [full-root: 9.8% (5.3-18.2) versus subcoronary: 9.7% (3.1-30.5), P = 0.85) between the groups, also after matching.
Conclusions: Independent of the technique, Ross procedure is performed with excellent survival and low autograft reoperation rates in high-volume centres. The longer, technically more challenging subcoronary Ross demonstrated no differences in early postoperative complications. A superiority in autograft durability has so far not been noticed either in the medium-term follow-up.
目的:随着两种不同的Ross自体移植物植入技术:冠状动脉下与全根的发展,问题仍然是哪种策略能表现出更好的早期/中期表现,特别是在自体移植物耐久性方面。方法:纳入2012年1月1日至2022年12月在两个大容量中心接受Ross手术的患者(0-18岁)。研究人员分析了冠状动脉下和全根Ross手术患者的早期死亡率、直接术后并发症、5年生存率、再介入/再手术发生率、自体移植物耐久性。采用倾向得分匹配和回归分析克服了制度差异。结果:共纳入205例儿科患者(Ross的中位年龄:7.6岁[1.9-13.5],67%为男性)。两组之间的基线特征没有差异,除了先前的主动脉瓣修复在全根ross中发生的频率更高(19% vs 6.9%;p = 0.03)。体外循环持续时间(中位265 vs 221分钟,p)结论:独立于技术,Ross手术在大容量中心具有良好的生存率和较低的自体移植物再手术率。更长,技术上更具挑战性的冠状动脉下罗斯在早期术后并发症方面没有差异。到目前为止,在中期随访中也没有注意到自体移植物耐久性的优势。
期刊介绍:
The primary aim of the European Journal of Cardio-Thoracic Surgery is to provide a medium for the publication of high-quality original scientific reports documenting progress in cardiac and thoracic surgery. The journal publishes reports of significant clinical and experimental advances related to surgery of the heart, the great vessels and the chest. The European Journal of Cardio-Thoracic Surgery is an international journal and accepts submissions from all regions. The journal is supported by a number of leading European societies.