Nilima Jawale, Jeffrey Shenberger, Ricardo Rodriguez, Avinash K Shetty, Parvesh M Garg
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引用次数: 0
Abstract
Necrotizing enterocolitis (NEC) is among the most devastating neonatal illnesses of premature infants. Although it is a disease of multifactorial etiology associated with bacterial dysbiosis, several reports of viral and some fungal infections associated with NEC have been published. Despite the abundance of viruses - primarily bacteriophages, and 'virus-like particles' in the normal infant gut flora, there is limited understanding of the contribution of these elements to newborn gut health and disease. This article aims to review existing evidence on normal newborn virome and mycobiome development, and present insights into the complex inter kingdom interactions between gut bacteria, viruses and fungi in the intestinal ecosystem, exploring their potential role in predisposing the preterm infant to NEC.
期刊介绍：
The American Journal of Perinatology is an international, peer-reviewed, and indexed journal publishing 14 issues a year dealing with original research and topical reviews. It is the definitive forum for specialists in obstetrics, neonatology, perinatology, and maternal/fetal medicine, with emphasis on bridging the different fields.
The focus is primarily on clinical and translational research, clinical and technical advances in diagnosis, monitoring, and treatment as well as evidence-based reviews. Topics of interest include epidemiology, diagnosis, prevention, and management of maternal, fetal, and neonatal diseases. Manuscripts on new technology, NICU set-ups, and nursing topics are published to provide a broad survey of important issues in this field.
All articles undergo rigorous peer review, with web-based submission, expedited turn-around, and availability of electronic publication.
The American Journal of Perinatology is accompanied by AJP Reports - an Open Access journal for case reports in neonatology and maternal/fetal medicine.
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