Cytokine Signature Unveils Subgroups of Patients With Immune-Mediated Sensory Neuronopathies

IF 3.9 3区医学 Q1 CLINICAL NEUROLOGY

Journal of the Peripheral Nervous System Pub Date : 2025-03-04 DOI:10.1111/jns.70008

Christian P. Moritz, Yannick Tholance, Coralie Borowczyk, Fabienne Jospin, Stéphane Paul, Jean-Christophe Antoine, Jean-Philippe Camdessanché

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引用次数: 0

Abstract

Background and Aims

Immune-mediated sensory neuronopathies (SNN) can occur alongside autoimmune disorders (e.g., Sjögren syndrome), involve autoantibodies (such as anti-FGFR3 or anti-AGO antibodies), or present in isolation. The underlying mechanisms remain unclear. This study aimed to investigate the role of proinflammatory cytokines in these conditions.

Methods

Blood levels of IL-1β, IL-6, IL-17, TNF-α, INF α-2, and INF-γ were measured using a Bioplex T200 platform and the Bio-Plex Pro Reagent Kit III in 113 patients with SNN between 2.4 and 464.4 months after symptom onset, categorized based on disease course (acute, subacute, chronic). Eighteen patients had anti-AGO antibodies, 48 had anti-FGFR3 antibodies, and 14 had an autoimmune disease without detectable anti-AGO or FGFR3 antibodies. Disease extent was measured by the SNN score, while the disease severity was evaluated using the modified Rankin score. Immunoreactivity against IL-6 and INF-γ was measured via ELISA.

Results

Multicomponent analysis utilizing cytokines levels identified four distinct patient subgroups characterized by differences in age at onset and SNN score. No significant differences were observed among the subgroups regarding disease course and severity, presence of anti-AGO or anti-FGFR3 antibodies, or association with an autoimmune disease. A small subgroup of three younger patients exhibited the highest levels of TNF-α, IL-6, and IL-1β. Another subgroup of seven patients displayed elevated INF α-2 levels and tended towards highest SNN scores. The largest group (95 subjects) comprised older individuals with relatively lower cytokine levels and decreased anti-IL-6 immunoreactivity.

Interpretation

These cytokine profiles suggest diverse underlying mechanisms within immune-mediated SNN. Further investigation is warranted to determine whether certain profiles, particularly those involving young patients with elevated proinflammatory cytokines, might benefit from targeted treatments.

Abstract Image

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细胞因子特征揭示了免疫介导的感觉神经病变患者的亚群

背景和目的免疫介导的感觉神经病变（SNN）可与自身免疫性疾病（如Sjögren综合征）一起发生，涉及自身抗体（如抗fgfr3或抗ago抗体），或单独存在。其潜在机制尚不清楚。本研究旨在探讨促炎细胞因子在这些疾病中的作用。方法采用Bioplex T200平台和Bio-Plex Pro Reagent Kit III检测症状出现后2.4 ~ 464.4个月的113例SNN患者血液中IL-1β、IL-6、IL-17、TNF-α、INF α-2和INF-γ的水平，根据病程（急性、亚急性、慢性）进行分类。18名患者有抗ago抗体，48名患者有抗FGFR3抗体，14名患者患有自身免疫性疾病，未检测到抗ago或FGFR3抗体。采用SNN评分测量疾病程度，采用改良Rankin评分评估疾病严重程度。ELISA法检测小鼠对IL-6和INF-γ的免疫反应性。结果利用细胞因子水平的多成分分析确定了发病年龄和SNN评分差异的四个不同患者亚组。亚组之间在病程和严重程度、抗ago或抗fgfr3抗体的存在或与自身免疫性疾病的关联方面没有观察到显著差异。三名年轻患者的小亚组表现出最高水平的TNF-α， IL-6和IL-1β。另一个亚组7名患者表现出INF α-2水平升高，并倾向于最高的SNN评分。最大的一组（95名受试者）由细胞因子水平相对较低且抗il -6免疫反应性降低的老年人组成。这些细胞因子谱表明免疫介导SNN的多种潜在机制。需要进一步的研究来确定某些情况，特别是那些涉及促炎细胞因子升高的年轻患者，是否可能从靶向治疗中受益。

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来源期刊

Journal of the Peripheral Nervous System 医学-临床神经学

CiteScore

6.10

自引率

7.90%

发文量

审稿时长

>12 weeks

期刊介绍： The Journal of the Peripheral Nervous System is the official journal of the Peripheral Nerve Society. Founded in 1996, it is the scientific journal of choice for clinicians, clinical scientists and basic neuroscientists interested in all aspects of biology and clinical research of peripheral nervous system disorders. The Journal of the Peripheral Nervous System is a peer-reviewed journal that publishes high quality articles on cell and molecular biology, genomics, neuropathic pain, clinical research, trials, and unique case reports on inherited and acquired peripheral neuropathies. Original articles are organized according to the topic in one of four specific areas: Mechanisms of Disease, Genetics, Clinical Research, and Clinical Trials. The journal also publishes regular review papers on hot topics and Special Issues on basic, clinical, or assembled research in the field of peripheral nervous system disorders. Authors interested in contributing a review-type article or a Special Issue should contact the Editorial Office to discuss the scope of the proposed article with the Editor-in-Chief.