Hyperspectral Imaging in the Healing Prognosis of Diabetes Related Foot Ulcers. A Systematic Review and Meta-Analysis

IF 1.9 4区医学 Q3 HEMATOLOGY

Microcirculation Pub Date : 2025-03-05 DOI:10.1111/micc.70005

Patricia M. González-Villacorta, Mateo López-Moral, Marta García-Madrid, Esther García-Morales, Aroa Tardáguila-García, José Luis Lázaro-Martínez

{"title":"Hyperspectral Imaging in the Healing Prognosis of Diabetes Related Foot Ulcers. A Systematic Review and Meta-Analysis","authors":"Patricia M. González-Villacorta, Mateo López-Moral, Marta García-Madrid, Esther García-Morales, Aroa Tardáguila-García, José Luis Lázaro-Martínez","doi":"10.1111/micc.70005","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Objective</h3>\n \n <p>The diagnostic capability of hyperspectral (HSI) imaging has been focused on the prognosis of wound healing in patients with peripheral artery disease and diabetic foot ulcers (DFUs). The aim of this study was to evaluate the performance characteristics of HSI to determine the pretest probability for the prognosis of DFU healing.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>A systematic search was performed on the PubMed, Medline, and Cochrane databases to identify studies evaluating HSI in predicting the prognosis of DFUs. This study was registered with PROSPERO (CRD42023495391). All selected studies were evaluated using the STROBE guidelines to assess the reporting quality for observational studies. Meta-DiSc software was used to analyze the collected data.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Nine publications (142 participants) were evaluated for systematic review. The meta-analysis included four publications examining the prospective diagnostic capability of HSI. Concerning the prognostic accuracy of HSI, it had a pooled sensitivity of 0.84 (0.75–0.9) and a specificity of 0.79 (0.66–0.88) for predicting DFU healing, as well as an odds ratio of 20.4, resulting in a positive likelihood ratio of 4.1 and a negative likelihood ratio of 0.2 (heterogeneity <i>I</i><sup>2</sup> = 0).</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>The meta-analysis revealed promising prognostic capability of HSI for the healing of DFU. More randomized clinical trials need to be published as our results are based on only prospective and comparative studies.</p>\n </section>\n </div>","PeriodicalId":18459,"journal":{"name":"Microcirculation","volume":"32 3","pages":""},"PeriodicalIF":1.9000,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Microcirculation","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/micc.70005","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"HEMATOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Objective

The diagnostic capability of hyperspectral (HSI) imaging has been focused on the prognosis of wound healing in patients with peripheral artery disease and diabetic foot ulcers (DFUs). The aim of this study was to evaluate the performance characteristics of HSI to determine the pretest probability for the prognosis of DFU healing.

Methods

A systematic search was performed on the PubMed, Medline, and Cochrane databases to identify studies evaluating HSI in predicting the prognosis of DFUs. This study was registered with PROSPERO (CRD42023495391). All selected studies were evaluated using the STROBE guidelines to assess the reporting quality for observational studies. Meta-DiSc software was used to analyze the collected data.

Results

Nine publications (142 participants) were evaluated for systematic review. The meta-analysis included four publications examining the prospective diagnostic capability of HSI. Concerning the prognostic accuracy of HSI, it had a pooled sensitivity of 0.84 (0.75–0.9) and a specificity of 0.79 (0.66–0.88) for predicting DFU healing, as well as an odds ratio of 20.4, resulting in a positive likelihood ratio of 4.1 and a negative likelihood ratio of 0.2 (heterogeneity I² = 0).

Conclusions

The meta-analysis revealed promising prognostic capability of HSI for the healing of DFU. More randomized clinical trials need to be published as our results are based on only prospective and comparative studies.

查看原文本刊更多论文

高光谱成像在糖尿病相关足溃疡愈合预后中的作用。系统回顾和荟萃分析

目的研究高光谱（HSI）成像对外周动脉病变合并糖尿病足溃疡（DFUs）患者伤口愈合的预后。本研究的目的是评估HSI的表现特征，以确定DFU愈合预后的预测概率。方法对PubMed、Medline和Cochrane数据库进行系统检索，以确定评估HSI预测DFUs预后的研究。本研究已在PROSPERO注册（CRD42023495391）。所有选择的研究都使用STROBE指南进行评估，以评估观察性研究的报告质量。Meta-DiSc软件对收集的数据进行分析。结果对9篇文献（142名受试者）进行系统评价。荟萃分析包括四篇研究HSI前瞻性诊断能力的出版物。关于HSI的预后准确性，预测DFU愈合的总敏感性为0.84(0.75-0.9)，特异性为0.79(0.66-0.88)，比值比为20.4，阳性似然比为4.1，阴性似然比为0.2（异质性I2 = 0）。结论荟萃分析显示HSI对DFU愈合具有良好的预后能力。由于我们的结果仅基于前瞻性和比较研究，因此需要发表更多的随机临床试验。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Microcirculation 医学-外周血管病

CiteScore

5.00

自引率

4.20%

发文量

审稿时长

6-12 weeks

期刊介绍： The journal features original contributions that are the result of investigations contributing significant new information relating to the vascular and lymphatic microcirculation addressed at the intact animal, organ, cellular, or molecular level. Papers describe applications of the methods of physiology, biophysics, bioengineering, genetics, cell biology, biochemistry, and molecular biology to problems in microcirculation. Microcirculation also publishes state-of-the-art reviews that address frontier areas or new advances in technology in the fields of microcirculatory disease and function. Specific areas of interest include: Angiogenesis, growth and remodeling; Transport and exchange of gasses and solutes; Rheology and biorheology; Endothelial cell biology and metabolism; Interactions between endothelium, smooth muscle, parenchymal cells, leukocytes and platelets; Regulation of vasomotor tone; and Microvascular structures, imaging and morphometry. Papers also describe innovations in experimental techniques and instrumentation for studying all aspects of microcirculatory structure and function.