General Toxic Properties of the Radiopharmaceutical 225Ac-DOTA-PSMA

IF 0.3 4区物理与天体物理 Q4 PHYSICS, NUCLEAR

Physics of Atomic Nuclei Pub Date : 2025-03-05 DOI:10.1134/S1063778824100508

V. K. Tishchenko, A. A. Pankratov, O. P. Vlasova, G. A. Demyashkin, A. V. Fedorova, E. A. Plotnikova, Yu. B. Venediktova, S. P. Orlenko, E. D. Stepchenkova, A. A. Ostroukhov, A. N. Shcherbakova, S. A. Ivanov, A. D. Kaprin

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Abstract

Radiopharmaceuticals (RPs) specific to prostate-specific membrane antigen (PSMA) are extremely promising for radioligand therapy of prostate cancer. The aim of this work was to study the general toxic properties of radiopharmaceutical ²²⁵Ac-DOTA-PSMA after its single intravenous administration to laboratory animals (“acute” toxicity). It was shown that the administration of ²²⁵Ac-DOTA-PSMA to mice and rats (males and females) in doses of 100, 200, and 500 kBq/kg was satisfactorily tolerated by the animals. No significant signs of intoxication or death of animals were observed. No pathomorphological changes in internal organs and tissues were detected at autopsy of animals. In mice treated with ²²⁵Ac-DOTA-PSMA at doses of 200 and 500 kBq/kg, a decrease in the mass of salivary glands by 8–15% was observed compared to the control group (p > 0.05).

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来源期刊

Physics of Atomic Nuclei 物理-物理：核物理

CiteScore

0.60

自引率

25.00%

发文量

审稿时长

3-6 weeks

期刊介绍： Physics of Atomic Nuclei is a journal that covers experimental and theoretical studies of nuclear physics: nuclear structure, spectra, and properties; radiation, fission, and nuclear reactions induced by photons, leptons, hadrons, and nuclei; fundamental interactions and symmetries; hadrons (with light, strange, charm, and bottom quarks); particle collisions at high and superhigh energies; gauge and unified quantum field theories, quark models, supersymmetry and supergravity, astrophysics and cosmology.