Hg2+-induced hydrolysis of fluorescein hydrazone: A new fluorescence probe for selective recognition Hg2+ in an aqueous solution

IF 4 2区化学 Q2 CHEMISTRY, PHYSICAL

Journal of Molecular Structure Pub Date : 2025-03-02 DOI:10.1016/j.molstruc.2025.141930

M.N. Zavalishin, A.E. Pogonin, G.A. Gamov

{"title":"Hg2+-induced hydrolysis of fluorescein hydrazone: A new fluorescence probe for selective recognition Hg2+ in an aqueous solution","authors":"M.N. Zavalishin, A.E. Pogonin, G.A. Gamov","doi":"10.1016/j.molstruc.2025.141930","DOIUrl":null,"url":null,"abstract":"<div><div>In this study, we report the synthesis of a new fluorescent probe, developed for the sensitive detection of Hg<sup>2+</sup> in aqueous environments. The probe molecule was thoroughly characterized by several spectral methods. The probe derived from fluorescein hydrazide and 2,4-dimethoxybenzaldehyde demonstrate a significant increase in fluorescence emission and absorbance upon interaction with Hg<sup>2+</sup>ions. This response is attributed to converting the closed spirolactam form to the open form of the fluorescein ring. The sensing mechanism was elucidated through <sup>1</sup>H NMR and MALDI-TOF MS analyses revealing Hg<sup>2+</sup>-promoted hydrolysis of the fluorescein hydrazone. The conformational diversity of the probe, which affects its spectral properties, was analyzed using quantum chemical methods. Notably, the probe displayed excellent selectivity towards Hg<sup>2+</sup>, a low detection limit of 0.16 <em>µ</em>M, and a rapid response time. Furthermore, it was successfully employed to monitor variations in Hg<sup>2+</sup> concentrations in river water samples, highlighting its potential application in environmental monitoring and safety assessments.</div></div>","PeriodicalId":16414,"journal":{"name":"Journal of Molecular Structure","volume":"1334 ","pages":"Article 141930"},"PeriodicalIF":4.0000,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Molecular Structure","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0022286025006167","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}

引用次数: 0

Abstract

In this study, we report the synthesis of a new fluorescent probe, developed for the sensitive detection of Hg²⁺ in aqueous environments. The probe molecule was thoroughly characterized by several spectral methods. The probe derived from fluorescein hydrazide and 2,4-dimethoxybenzaldehyde demonstrate a significant increase in fluorescence emission and absorbance upon interaction with Hg²⁺ions. This response is attributed to converting the closed spirolactam form to the open form of the fluorescein ring. The sensing mechanism was elucidated through ¹H NMR and MALDI-TOF MS analyses revealing Hg²⁺-promoted hydrolysis of the fluorescein hydrazone. The conformational diversity of the probe, which affects its spectral properties, was analyzed using quantum chemical methods. Notably, the probe displayed excellent selectivity towards Hg²⁺, a low detection limit of 0.16 µM, and a rapid response time. Furthermore, it was successfully employed to monitor variations in Hg²⁺ concentrations in river water samples, highlighting its potential application in environmental monitoring and safety assessments.

Abstract Image

查看原文本刊更多论文

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Molecular Structure 化学-物理化学

CiteScore

7.10

自引率

15.80%

发文量

2384

审稿时长

45 days

期刊介绍： The Journal of Molecular Structure is dedicated to the publication of full-length articles and review papers, providing important new structural information on all types of chemical species including: • Stable and unstable molecules in all types of environments (vapour, molecular beam, liquid, solution, liquid crystal, solid state, matrix-isolated, surface-absorbed etc.) • Chemical intermediates • Molecules in excited states • Biological molecules • Polymers. The methods used may include any combination of spectroscopic and non-spectroscopic techniques, for example: • Infrared spectroscopy (mid, far, near) • Raman spectroscopy and non-linear Raman methods (CARS, etc.) • Electronic absorption spectroscopy • Optical rotatory dispersion and circular dichroism • Fluorescence and phosphorescence techniques • Electron spectroscopies (PES, XPS), EXAFS, etc. • Microwave spectroscopy • Electron diffraction • NMR and ESR spectroscopies • Mössbauer spectroscopy • X-ray crystallography • Charge Density Analyses • Computational Studies (supplementing experimental methods) We encourage publications combining theoretical and experimental approaches. The structural insights gained by the studies should be correlated with the properties, activity and/ or reactivity of the molecule under investigation and the relevance of this molecule and its implications should be discussed.