Targeted mitochondrial therapy for pancreatic cancer

IF 5 2区 医学 Q2 Medicine
Xinya Zhao , Guoyu Wu , Xufeng Tao , Deshi Dong , Jing Liu
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引用次数: 0

Abstract

Pancreatic cancer (PC) is a highly invasive tumor characterized by delayed diagnosis, rapid progress, and resistance to chemotherapy. Mitochondria, as the "power chamber" of cells, not only play a central role in energy metabolism but also participate in the production of reactive oxygen species (ROS), calcium signaling, regulation, and differentiation of the cell cycle. The abnormal activity of mitochondria is closely related to the development of PC. In this paper, we discussed the key role of mitochondria in PC, including mitochondrial DNA, mitochondrial biogenesis, mitochondrial dynamics, metabolic regulation, ROS generation, and mitochondrial-dependent apoptosis. We elaborated on the importance of these mitochondrial mechanisms in the development of PC and emphasized the potential of targeted mitochondrial therapy strategies for these mechanisms in the treatment of PC. In addition, this article also reviews the latest developments in innovative drug carriers such as cell-penetrating peptides, nucleic acid aptamers, and nanomaterials, which can achieve precise localization of mitochondria and drug delivery. Therefore, this article comprehensively analyzed the important role of mitochondria in the treatment of PC and clarified the effectiveness and necessity of targeting mitochondria in the treatment of PC.

Abstract Image

靶向线粒体治疗胰腺癌
胰腺癌(PC)是一种高度侵袭性的肿瘤,其特点是诊断延迟,进展迅速,对化疗有耐药性。线粒体作为细胞的“动力室”,不仅在能量代谢中发挥核心作用,还参与活性氧(reactive oxygen species, ROS)的产生、钙信号的传递、细胞周期的调控和分化。线粒体的异常活动与PC的发生密切相关。在本文中,我们讨论了线粒体在PC中的关键作用,包括线粒体DNA、线粒体生物发生、线粒体动力学、代谢调节、ROS生成和线粒体依赖性凋亡。我们详细阐述了这些线粒体机制在PC发展中的重要性,并强调了针对这些机制治疗PC的靶向线粒体治疗策略的潜力。此外,本文还综述了细胞穿透肽、核酸适体和纳米材料等创新药物载体的最新进展,这些材料可以实现线粒体的精确定位和药物递送。因此,本文综合分析了线粒体在PC治疗中的重要作用,阐明了靶向线粒体治疗PC的有效性和必要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
8.40
自引率
2.00%
发文量
314
审稿时长
54 days
期刊介绍: Translational Oncology publishes the results of novel research investigations which bridge the laboratory and clinical settings including risk assessment, cellular and molecular characterization, prevention, detection, diagnosis and treatment of human cancers with the overall goal of improving the clinical care of oncology patients. Translational Oncology will publish laboratory studies of novel therapeutic interventions as well as clinical trials which evaluate new treatment paradigms for cancer. Peer reviewed manuscript types include Original Reports, Reviews and Editorials.
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