BGMDB: A curated database linking gut microbiota dysbiosis to brain disorders

Abstract

The gut microbiota is a fundamental component of human health and has been increasingly implicated in the etiology of neurological disorders. Neurotransmitters, acting as key mediators of gut-brain communication, are closely associated with both the progression and therapeutic modulation of brain diseases. Despite significant advancements in microbiome research, the complex interplay between gut microbiota and neurological disorders remains poorly understood, and a comprehensive resource integrating these associations is lacking. To bridge this gap, we developed the Brain Disease Gut Microbiota Database (BGMDB), a rigorously curated repository documenting experimentally validated relationships between gut microbiota and brain diseases. BGMDB encompasses 1419 associations involving 609 gut microbiota taxa and 43 brain disorders, along with 184 tripartite interactions linking brain diseases, neurotransmitters, and microbiota across six neurotransmitter systems. Additionally, BGMDB integrates genetic data from the gutMGene database, allowing users to explore microbiota-mediated genetic associations with brain disease pathology and neuroanatomical alterations. A user-friendly interface enables researchers to navigate relevant information through graphical query tools, comprehensive browsing functionalities, and data retrieval options. Our BGMDB provides an unparalleled resource for advancing mechanistic insights into gut-brain interactions, facilitating novel microbiota-targeted therapeutic strategies for neurological disorders. BGMDB is freely available at: http://bgmdb.online/bgmdb.