Efficacy and safety of vertebral augmentation techniques in patients with osteoporotic vertebral compression fractures: A single center, retrospective, observational study

Eliezer Soto , Michael F. Esposito
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引用次数: 0

Abstract

Background

Back pain secondary to osteoporotic vertebral compression fractures (OVCF) is a common global health problem that is frequently overlooked. For some patients, conservative management (CM) is inadequate to treat the pain associated with OVCF. This subset of patients are often candidates for interventional vertebral augmentation techniques (VAT). Multiple studies have shown significant pain reduction, height restoration, reduction in hospitalization time, morbidity and mortality in patients treated with VAT as compared with those patients treated with CM. This study examines if the previously published trials are consistent with outcomes in a real-world cohort of patients in interventional pain practices following VAT.

Objectives

The purpose of this retrospective databased analysis was to further investigate the efficacy and safety of percutaneous vertebral augmentation techniques in patients suffering from osteoporotic vertebral compression fractures in our center.

Study design

Retrospective study.

Setting

A single-center study.

Patients and methods

We have included data from a total of 42 patients (26 females, 16 males) with diagnosis of OVCF that received VAT at our center between January 2023 and June 2024. Efficacy data included pre-procedure, 2-week, 1-month and 3-month follow-up numerical rating scale (NRS) pain scores when available.

Results

The mean pain score using NRS was 7.5 (n = 45), 3.24 (n = 44), 3.65 (n = 21) and 2.7 (n = 15) at pre-procedure, 2-week, 1-month and 3-month follow-up (P < 0.001), respectively. At the 2-week follow up, 44 %, 16 %, 20 % and 13 % of patients (n = 45) had NRS pain score reduction between 76 and 100 %, 51–75 %, 26–50 % and 0–25 % (P ≤ 0.05), respectively. At the 1-month follow-up visit, 24 %, 33 %, 14.3 % and 24 % of patients (n = 21) had NRS pain score reduction between 76 and 100 %, 51–75 %, 26–50 % and 0–25 % (P ≤ 0.05), respectively. At the 3-month follow-up visit, 60 %, 6.7 %, 6.7 % and 20 % of patients (n = 15) had NRS pain score reduction between 76 and 100 %, 51–75 %, 26–50 % and 0–25 % (P ≤ 0.05), respectively. This indicates significant differences in NRS pain scores across the different time points. There was a high dropout rate at the 3-month follow up visit most likely due to patient's pain improving post procedure.

Limitations

This was a single-center retrospective study with a small sample size and relatively short follow-up time.

Conclusion

VAT are effective and safe procedures for patients suffering from OCVF. However, proceduralists must be aware of patient-specific risk factors to prevent possible complications.
椎体增强技术治疗骨质疏松性椎体压缩性骨折的疗效和安全性:一项单中心、回顾性、观察性研究
骨质疏松性椎体压缩性骨折(OVCF)继发的腰痛是一个常见的全球健康问题,但经常被忽视。对于一些患者,保守治疗(CM)不足以治疗与OVCF相关的疼痛。这部分患者通常是介入性椎体增强技术(VAT)的候选者。多项研究表明,与CM治疗患者相比,VAT治疗患者在疼痛减轻、身高恢复、住院时间、发病率和死亡率方面均有显著降低。本研究考察了先前发表的试验是否与VAT后介入性疼痛实践患者的真实队列结果一致。目的本研究旨在进一步探讨经皮椎体增强技术治疗骨质疏松性椎体压缩性骨折的疗效和安全性。研究设计回顾性研究。单中心研究。患者和方法我们纳入了2023年1月至2024年6月期间在我们中心接受VAT治疗的共42例OVCF患者(26例女性,16例男性)的数据。疗效数据包括术前、2周、1个月和3个月随访的数值评定量表(NRS)疼痛评分(如有)。结果术前、随访2周、1个月和3个月时,NRS评分分别为7.5分(n = 45)、3.24分(n = 44)、3.65分(n = 21)和2.7分(n = 15)。分别为0.001)。随访2周时,有44%、16%、20%和13% (n = 45)的患者NRS疼痛评分降低,分别为76 ~ 100%、51 ~ 75%、26 ~ 50%和0 ~ 25% (P≤0.05)。1个月随访时,有24%、33%、14.3%和24% (n = 21)的患者NRS疼痛评分降低,分别为76 ~ 100%、51 ~ 75%、26 ~ 50%和0 ~ 25% (P≤0.05)。随访3个月时,60%、6.7%、6.7%、20% (n = 15)的患者NRS疼痛评分降低,分别为76 ~ 100%、51 ~ 75%、26 ~ 50%、0 ~ 25% (P≤0.05)。这表明NRS疼痛评分在不同时间点上存在显著差异。在3个月的随访中,有很高的辍学率,这很可能是由于患者术后疼痛的改善。局限性:本研究为单中心回顾性研究,样本量小,随访时间相对较短。结论vat是治疗OCVF有效、安全的手术方法。然而,手术医师必须意识到患者特有的危险因素,以防止可能的并发症。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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