Abuse-deterrent wearable device with potential for extended delivery of opioid drugs.

IF 3.2 4区医学 Q2 ENGINEERING, BIOMEDICAL

Biomedical Engineering Letters Pub Date : 2025-02-04 eCollection Date: 2025-03-01 DOI:10.1007/s13534-025-00459-7

Myoung Ju Kim, Jae Min Park, Jun Su Lee, Ji Yang Lee, Juhui Lee, Chang Hee Min, Min Ji Kim, Jae Hoon Han, Eun Jung Kwon, Young Bin Choy

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引用次数: 0

Abstract

Purpose: Unethical attempts to misuse and overdose opioids have led to strict prescription limits, necessitating frequent hospital visits and prescriptions for long-term severe pain management. Therefore, this study aimed to develop a prototype wearable device that facilitates the extended delivery of opioid drugs while incorporating abuse-deterrent functionality, referred to as the abuse deterrent device (ADD).

Methods: The ADD was designed and fabricated using 3D-printed components, including reservoirs for the drug and contaminant, as well as an actuator. In vitro tests were conducted using a skin-mimicking layer and phosphate-buffered saline (PBS) to evaluate the drug release profile and the effectiveness of the ADD abuse-deterrent mechanism.

Results: Under simulated skin attachment, ADD demonstrated sustained drug release with the potential to persist for up to 200 days. Upon detachment from the skin mimic, the mechanical components of the ADD facilitated immediate exposure of the contaminant to the drug and effectively halted further drug exposure throughout-diffusion.

Conclusion: Wearable ADD provides a secure and practical solution for the long-term treatment of high-risk medications such as opioids, enhances patient convenience, and addresses important public health concerns.

Supplementary information: The online version contains supplementary material available at 10.1007/s13534-025-00459-7.

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具有延长阿片类药物输送潜力的防滥用可穿戴设备。

目的：不道德的滥用和过量阿片类药物的企图导致了严格的处方限制，需要经常去医院就诊和长期严重疼痛治疗处方。因此，本研究旨在开发一种原型可穿戴设备，促进阿片类药物的延长递送，同时结合滥用威慑功能，称为滥用威慑装置（ADD）。方法：采用3d打印的方法设计并制作药物、污染物储存库和致动器。采用皮肤模拟层和磷酸盐缓冲盐水（PBS）进行体外试验，以评估药物释放情况和ADD滥用威慑机制的有效性。结果：在模拟皮肤附着下，ADD表现出持续的药物释放，并可能持续长达200天。在脱离皮肤模拟物后，ADD的机械成分促进污染物立即暴露于药物，并在扩散过程中有效地阻止进一步的药物暴露。结论：可穿戴式ADD为阿片类药物等高危药物的长期治疗提供了安全实用的解决方案，增强了患者的便利性，解决了重要的公共卫生问题。补充信息：在线版本包含补充资料，提供地址为10.1007/s13534-025-00459-7。

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来源期刊

Biomedical Engineering Letters ENGINEERING, BIOMEDICAL-

CiteScore

6.80

自引率

0.00%

发文量

期刊介绍： Biomedical Engineering Letters (BMEL) aims to present the innovative experimental science and technological development in the biomedical field as well as clinical application of new development. The article must contain original biomedical engineering content, defined as development, theoretical analysis, and evaluation/validation of a new technique. BMEL publishes the following types of papers: original articles, review articles, editorials, and letters to the editor. All the papers are reviewed in single-blind fashion.