{"title":"mSphere of Influence: The ever-expanding universe of parasite cell biology.","authors":"Benjamin Liffner","doi":"10.1128/msphere.00043-25","DOIUrl":null,"url":null,"abstract":"<p><p>Ben Liffner studies the cell biology of apicomplexan parasites. In this mSphere of Influence article, he reflects on two key papers: \"Three-dimensional ultrastructure of <i>Plasmodium falciparum</i> throughout cytokinesis\" by R. M. Rudlaff, S. Kraemer, J. Marshman, J. D. Dvorin, et al. (PLoS Pathog 16:e1008587, 2020, https://doi.org/10.1371/journal.ppat.1008587) and \"Expansion microscopy provides new insights into the cytoskeleton of malaria parasites including the conservation of a conoid\" by E. Bertiaux, A. C. Balestra, L. Bournonville, V. Louvel, et al. (PLoS Biol 19:e3001020, 2021, https://doi.org/10.1371/journal.pbio.3001020). These two studies provided Ben with the conceptual framework to understand how parasites are organized in three dimensions, and the technique of ultrastructure expansion microscopy that he has since used to investigate this intriguing area of biology.</p>","PeriodicalId":19052,"journal":{"name":"mSphere","volume":" ","pages":"e0004325"},"PeriodicalIF":3.7000,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11934323/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"mSphere","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1128/msphere.00043-25","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/3/4 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"MICROBIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Ben Liffner studies the cell biology of apicomplexan parasites. In this mSphere of Influence article, he reflects on two key papers: "Three-dimensional ultrastructure of Plasmodium falciparum throughout cytokinesis" by R. M. Rudlaff, S. Kraemer, J. Marshman, J. D. Dvorin, et al. (PLoS Pathog 16:e1008587, 2020, https://doi.org/10.1371/journal.ppat.1008587) and "Expansion microscopy provides new insights into the cytoskeleton of malaria parasites including the conservation of a conoid" by E. Bertiaux, A. C. Balestra, L. Bournonville, V. Louvel, et al. (PLoS Biol 19:e3001020, 2021, https://doi.org/10.1371/journal.pbio.3001020). These two studies provided Ben with the conceptual framework to understand how parasites are organized in three dimensions, and the technique of ultrastructure expansion microscopy that he has since used to investigate this intriguing area of biology.
本·利夫纳研究顶端复合体寄生虫的细胞生物学。在这篇影响范围的文章中，他反思了两篇关键论文：R. M. Rudlaff， S. Kraemer， J. Marshman， J. D. Dvorin等人的“恶性疟原虫在细胞分裂过程中的三维超微结构”（PLoS Pathog 16:e1008587, 2020, https://doi.org/10.1371/journal.ppat.1008587）和E. Bertiaux, a . C. Balestra， L. Bournonville， V. Louvel等人的“扩展显微镜为疟疾寄生虫的细胞骨架提供了新的见解，包括一个conoid的保存”（PLoS Biol 19: e3001020,2021, https://doi.org/10.1371/journal.pbio.3001020）。这两项研究为本提供了理解寄生虫如何在三维空间中组织的概念框架，以及他后来用于研究这一有趣的生物学领域的超微结构扩展显微镜技术。
期刊介绍：
mSphere™ is a multi-disciplinary open-access journal that will focus on rapid publication of fundamental contributions to our understanding of microbiology. Its scope will reflect the immense range of fields within the microbial sciences, creating new opportunities for researchers to share findings that are transforming our understanding of human health and disease, ecosystems, neuroscience, agriculture, energy production, climate change, evolution, biogeochemical cycling, and food and drug production. Submissions will be encouraged of all high-quality work that makes fundamental contributions to our understanding of microbiology. mSphere™ will provide streamlined decisions, while carrying on ASM''s tradition for rigorous peer review.
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