Fast whole brain relaxometry with Magnetic Resonance Spin TomogrAphy in Time-domain (MR-STAT) at 3 T: a retrospective cohort study.

IF 2 4区医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Magnetic Resonance Materials in Physics, Biology and Medicine Pub Date : 2025-04-01 Epub Date: 2025-03-04 DOI:10.1007/s10334-025-01237-3

Martin B Schilder, Stefano Mandija, Sarah M Jacobs, Jordi P D Kleinloog, Hanna Liu, Oscar van der Heide, Beyza Köktaş, Federico D'Agata, Vera C W Keil, Evert-Jan P A Vonken, Jan Willem Dankbaar, Jeroen Hendrikse, Tom J Snijders, Cornelis A T van den Berg, Anja G van der Kolk, Alessandro Sbrizzi

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引用次数: 0

Abstract

Objective: To report T₁/T₂-values of normal and normal appearing brain tissues (NBTs, healthy volunteers; NABTs, patients) acquired with a whole-brain 5-minute Magnetic Resonance Spin TomogrAphy in Time-domain (MR-STAT) protocol, and to explore relaxometry behavior in a brain tumor and in a multiple sclerosis patient.

Methods: MR-STAT was acquired in 49 participants (39 patients with neurological pathologies, age range: 21-79 years) at 3 T. Mean T₁/T₂-values were computed for: normal and normal appearing grey matter (NGM/NAGM)/white matter (NWM/NAWM)/thalamus/putamen/caudate nucleus (CN)/globus pallidus (GP). Differences between sex, brain lobes, and left/right were assessed. The age-dependency of T₁/T₂-values in N(A)BTs was investigated. Relaxometry analysis was performed in two clinical case examples.

Results: Mean (standard deviation) T₁/T₂-values were measured in N(A)GM = 1086(73)/74(9) ms; N(A)WM = 658(24)/48(3) ms; thalamus = 783(51)/42(4) ms; putamen = 863(40)/46(3) ms; CN = 1042(97)/63(9) ms; GP = 652(36)/36(3) ms. Differences between sex were not significant. T₁/T₂-values between the left/right parietal lobe and the left/right temporal lobe were significantly different. The quadratic age-dependency of T₁-values in the CN (p = 0.00039) and GP (p = 0.00037), and of T₂-values in the thalamus (p = 0.00044) and GP (p = 0.003) were significant. Pathological tissues could be discerned from NABTs using T₁/T₂-values.

Discussion: T₁/T₂-values and data trends agree with literature, supporting the validity of MR-STAT as a clinical option for fast relaxometry despite the relatively low number of subjects in the study. Future work should aim to include healthy participants of a wider age-range and to include B₁-field corrections.

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快速全脑弛缓测量与磁共振自旋断层扫描在时域（MR-STAT）：一项回顾性队列研究。

目的：报告健康志愿者正常脑组织和外观正常脑组织（nbt）的T1/ t2值；NABTs（患者）通过全脑5分钟时域磁共振自旋断层扫描（MR-STAT）方案获得，并探索脑肿瘤和多发性硬化症患者的松弛测量行为。方法：49名参与者（39例神经系统病变患者，年龄21-79岁）在3 t时获得MR-STAT，计算正常和正常表现的灰质(NGM/NAGM)/白质(NWM/NAWM)/丘脑/壳核/尾状核(CN)/苍白球（GP）的平均T1/ t2值。评估了性别、脑叶和左右脑的差异。研究N(A)BTs T1/ t2值的年龄依赖性。对2例临床病例进行松弛分析。结果：N(A)GM = 1086(73)/74(9) ms，测得T1/ t2均值（标准差）；N(A)WM = 658(24)/48(3) ms；丘脑= 783(51)/42(4)ms；壳层= 863(40)/46(3)ms；CN = 1042(97)/63(9) ms；GP = 652(36)/36(3) ms.性别间差异不显著。左/右顶叶和左/右颞叶T1/ t2值差异有统计学意义。CN区t1值（p = 0.00039）和GP区（p = 0.00037）以及丘脑区t2值（p = 0.00044）和GP区（p = 0.003）的二次年龄依赖性显著。通过T1/ t2值可以从nabt中识别出病理组织。讨论：T1/ t2值和数据趋势与文献一致，尽管研究中受试者数量相对较少，但支持MR-STAT作为快速弛缓测量的临床选择的有效性。未来的工作应旨在包括更大年龄范围的健康参与者，并包括B1-field校正。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Magnetic Resonance Materials in Physics, Biology and Medicine 医学-核医学

CiteScore

4.60

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： MAGMA is a multidisciplinary international journal devoted to the publication of articles on all aspects of magnetic resonance techniques and their applications in medicine and biology. MAGMA currently publishes research papers, reviews, letters to the editor, and commentaries, six times a year. The subject areas covered by MAGMA include: advances in materials, hardware and software in magnetic resonance technology, new developments and results in research and practical applications of magnetic resonance imaging and spectroscopy related to biology and medicine, study of animal models and intact cells using magnetic resonance, reports of clinical trials on humans and clinical validation of magnetic resonance protocols.