Association between ABCB1 C3435 T polymorphism- and methotrexate-related toxicity in pediatric acute lymphoblastic leukemia: a meta-analysis.

IF 1.6 4区医学 Q3 HEMATOLOGY

Hematology Pub Date : 2025-12-01 Epub Date: 2025-03-03 DOI:10.1080/16078454.2025.2469373

Xuefen Yan, Nana Zhang, Gang Wang, Jiaheng Wang

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引用次数: 0

Abstract

Background: The effect of methotrexate (MTX)-related toxicity on childhood acute lymphoblastic leukemia (ALL) is controversial. Hence, this meta-analysis aimed to investigate the association between ABCB1 C3435 T polymorphism- and methotrexate-related toxicity in pediatric acute lymphoblastic leukemia.

Methods: Relevant studies were systematically searched and extracted from multiple databases including PubMed, EMBASE, Web of Science, Cochrane Library, China National Knowledge Infrastructure (CNKI), and Wanfang databases up to 1 June, 2024.

Results: A total of 13 articles met the criteria, including 1506 patients. The results showed that ABCB1 C3435 T polymorphism was significantly associated with MTX-induced hepatotoxicity (CT/TT vs. CC: OR: 2.15, 95% CI: 1.40-3.32). There was no significant difference between ABCB1 C3435 T polymorphism and mucositis, myelosuppression, nephrotoxicity, gastrointestinal toxicity in pediatric ALL treated with MTX.

Conclusions: Our meta-analysis suggests that the ABCB1 C3435 T mutation may enhance the MTX-induced hepatotoxicity in childhood acute lymphoblastic leukemia.

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小儿急性淋巴细胞白血病中 ABCB1 C3435 T 多态性与甲氨蝶呤相关毒性的关系：一项荟萃分析。

背景：甲氨蝶呤（MTX）相关毒性对儿童急性淋巴细胞白血病（ALL）的影响尚存争议。因此，本荟萃分析旨在探讨ABCB1 C3435 T多态性与小儿急性淋巴细胞白血病甲氨蝶呤相关毒性之间的关系。方法：系统检索并提取截至2024年6月1日的PubMed、EMBASE、Web of Science、Cochrane Library、中国知网（CNKI）、万方等数据库的相关研究。结果：共有13篇文章符合标准，包括1506例患者。结果显示，ABCB1 C3435 T多态性与mtx诱导的肝毒性显著相关（CT/TT vs. CC: OR: 2.15, 95% CI: 1.40-3.32）。ABCB1 C3435 T多态性与MTX治疗的小儿ALL粘膜炎、骨髓抑制、肾毒性、胃肠道毒性无显著差异。结论：我们的荟萃分析表明，ABCB1 C3435 T突变可能会增强mtx诱导的儿童急性淋巴细胞白血病的肝毒性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Hematology 医学-血液学

CiteScore

2.60

自引率

5.30%

发文量

140

审稿时长

3 months

期刊介绍： Hematology is an international journal publishing original and review articles in the field of general hematology, including oncology, pathology, biology, clinical research and epidemiology. Of the fixed sections, annotations are accepted on any general or scientific field: technical annotations covering current laboratory practice in general hematology, blood transfusion and clinical trials, and current clinical practice reviews the consensus driven areas of care and management.