Mental Health Disorders in Patients with Inflammatory Bowel Disease Onset in Childhood or Youth - A Nationwide Cohort Study from Denmark.

IF 3.4 2区医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Clinical Epidemiology Pub Date : 2025-02-25 eCollection Date: 2025-01-01 DOI:10.2147/CLEP.S491881

Julie Rasmussen, Anna Sofie Kjærgaard Hansen, Bente Mertz Nørgård, Rasmus Gaardskær Nielsen, Niels Qvist, Henrik Bøggild, Kirsten Fonager

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引用次数: 0

Abstract

Purpose: The study aims to explore the association between patients diagnosed with inflammatory bowel disease (IBD) in childhood or youth and mental health disorders.

Methods: The study is a register-based cohort study of patients with IBD-onset before 25 years of age and matched references. They were followed until 30 years of age. The incidence rate and incidence rate ratio (IRR) for a wide spectrum of mental health disorders were assessed based on diagnostic codes from the Danish National Patient Registry, reimbursed prescriptions for psychotropic medications, and composite measures combining diagnosis and medication. Furthermore, the relative excess risk due to interaction (RERI) for parental educational level and parental mental health disorders were estimated.

Results: A total of 4904 patients with Crohn's disease (CD), 5794 with ulcerative colitis (UC), and 94,802 matched references were identified. Patients with CD-onset before age 18 had a higher risk of anxiety disorders (IRR 1.58 (CI95%: 1.33-1.86)), while patients with CD-onset between age 18 to 24 had a higher risk of both anxiety and mood disorders. Patients with UC-onset before age 18 had a higher risk of anxiety disorders (IRR: 1.39 (CI95%: 1.19-1.64)). In general, patients with IBD had a higher risk of receiving psychotropic medication. Parental education had a subadditive interaction with the risk of emotional disorders for both patients with CD and UC, while maternal mental health disorders had a subadditive interaction for patients with UC.

Conclusion: Patients with CD and UC have a higher risk of mental health disorders, primarily due to an elevated risk of emotional disorders and a higher use of psychotropic medication. Surprisingly, the study demonstrated subadditive effect of parental education and for patients with UC maternal mental health disorders on the risk of emotional disorders.

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儿童期或青年期炎症性肠病患者的精神健康障碍——丹麦的一项全国性队列研究

目的：本研究旨在探讨儿童或青少年炎症性肠病（IBD）患者与精神健康障碍之间的关系。方法：该研究是一项基于登记的队列研究，研究对象是25岁之前ibd发病的患者和匹配的参考文献。他们被跟踪到30岁。根据丹麦国家患者登记处的诊断代码、报销的精神药物处方以及结合诊断和药物治疗的综合措施，评估了各种精神健康障碍的发病率和发病率比（IRR）。此外，我们还评估了父母教育水平和父母心理健康障碍的相对过度互动风险（rei）。结果：共确定了4904例克罗恩病（CD）患者，5794例溃疡性结肠炎（UC）患者和94802例匹配参考文献。18岁前发病的cd患者出现焦虑障碍的风险较高（IRR为1.58 (CI95%: 1.33-1.86)），而18岁至24岁发病的cd患者出现焦虑和情绪障碍的风险较高。18岁前出现uc的患者出现焦虑障碍的风险较高（IRR: 1.39 (CI95%: 1.19-1.64)）。总的来说，IBD患者接受精神药物治疗的风险更高。父母教育与乳糜泻和UC患者的情绪障碍风险存在亚加性相互作用，而母亲精神健康障碍与UC患者的情绪障碍风险存在亚加性相互作用。结论：乳糜泻和UC患者有更高的精神健康障碍风险，主要是由于情绪障碍的风险增加和精神药物的使用增加。令人惊讶的是，该研究证明了父母教育和UC产妇心理健康障碍患者对情绪障碍风险的亚加性影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Epidemiology Medicine-Epidemiology

CiteScore

6.30

自引率

5.10%

发文量

169

审稿时长

16 weeks

期刊介绍： Clinical Epidemiology is an international, peer reviewed, open access journal. Clinical Epidemiology focuses on the application of epidemiological principles and questions relating to patients and clinical care in terms of prevention, diagnosis, prognosis, and treatment. Clinical Epidemiology welcomes papers covering these topics in form of original research and systematic reviews. Clinical Epidemiology has a special interest in international electronic medical patient records and other routine health care data, especially as applied to safety of medical interventions, clinical utility of diagnostic procedures, understanding short- and long-term clinical course of diseases, clinical epidemiological and biostatistical methods, and systematic reviews. When considering submission of a paper utilizing publicly-available data, authors should ensure that such studies add significantly to the body of knowledge and that they use appropriate validated methods for identifying health outcomes. The journal has launched special series describing existing data sources for clinical epidemiology, international health care systems and validation studies of algorithms based on databases and registries.