Visualizing the endothelial glycocalyx in human glioma vasculature.

IF 2.7 3区 医学 Q2 CLINICAL NEUROLOGY
Brain Tumor Pathology Pub Date : 2025-04-01 Epub Date: 2025-03-04 DOI:10.1007/s10014-025-00498-z
Kazufumi Ohmura, Hiroyuki Tomita, Hideshi Okada, Noriyuki Nakayama, Naoyuki Ohe, Tsuyoshi Izumo, Akira Hara
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引用次数: 0

Abstract

Gliomas are the most common primary brain tumors in adults. However, glioblastoma is especially difficult to treat despite advancements in treatment. Therefore, new and more effective treatments are needed. The endothelial glycocalyx covers the luminal surface of the endothelium and plays an important role in vascular homeostasis. Tumor blood vessels normally have increased permeability, but some of them mimic normal cerebral blood vessels constituting the blood-brain barrier and retain drug-barrier function. Therefore, brain tumor vessels are considered to constitute the blood-tumor barrier. There are few reports on the endothelial glycocalyx in human brain tumor vessels. We aimed to visualize the endothelial glycocalyx in human brain tumor vessels and evaluate its microstructural differences in glioma vessels and normal capillaries. Surgical specimens from patients with glioma who underwent tumor resection at our institution were evaluated. We visualized the microstructures of the brain tumor vessels in human glioma specimens using electron microscopy with lanthanum nitrate. The endothelial glycocalyx was identified in the human glioma vasculature and its microstructure varied between the tumor margin and core. These variations may influence tumor angiogenesis and vascular remodeling, contributing to advancements in targeted therapies and diagnostics for human gliomas.

人胶质瘤血管中内皮糖萼的可视化。
胶质瘤是成人最常见的原发性脑肿瘤。然而,胶质母细胞瘤尤其难以治疗,尽管治疗取得了进展。因此,需要新的和更有效的治疗方法。内皮糖萼覆盖在内皮管腔表面,在血管内稳态中起重要作用。肿瘤血管通常具有增加的通透性,但其中一些血管模仿正常的脑血管,构成血脑屏障并保留药物屏障功能。因此,脑肿瘤血管被认为构成了血瘤屏障。关于人脑肿瘤血管内皮糖萼的报道很少。我们的目的是观察人脑肿瘤血管内皮糖萼,并评估其在胶质瘤血管和正常毛细血管中的微结构差异。我们对在我院接受肿瘤切除术的胶质瘤患者的手术标本进行了评估。我们利用硝酸镧电子显微镜观察了人类神经胶质瘤标本中脑肿瘤血管的微观结构。在人胶质瘤血管中发现了内皮糖萼,其显微结构在肿瘤边缘和核心之间存在差异。这些变异可能影响肿瘤血管生成和血管重塑,有助于人类胶质瘤的靶向治疗和诊断的进步。
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来源期刊
Brain Tumor Pathology
Brain Tumor Pathology 医学-病理学
CiteScore
5.40
自引率
9.10%
发文量
30
审稿时长
>12 weeks
期刊介绍: Brain Tumor Pathology is the official journal of the Japan Society of Brain Tumor Pathology. This international journal documents the latest research and topical debate in all clinical and experimental fields relating to brain tumors, especially brain tumor pathology. The journal has been published since 1983 and has been recognized worldwide as a unique journal of high quality. The journal welcomes the submission of manuscripts from any country. Membership in the society is not a prerequisite for submission. The journal publishes original articles, case reports, rapid short communications, instructional lectures, review articles, letters to the editor, and topics.Review articles and Topics may be recommended at the annual meeting of the Japan Society of Brain Tumor Pathology. All contributions should be aimed at promoting international scientific collaboration.
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