Impact of binge drinking on alcoholic liver disease

IF 6.9 3区 医学 Q1 CHEMISTRY, MEDICINAL
Jisoo Kang, Seol Hee Park, Mushira Khanam, Seo Bhin Park, Sumin Shin, Wonhyo Seo
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Abstract

Numerous studies have examined the pathophysiological changes induced by chronic alcohol (ethanol) consumption and the underlying mechanisms, while much less attention has been devoted to understanding the health impacts of binge drinking. Binge drinking is defined as the excessive consumption of alcohol within a single drinking episode, and is the typical consumption pattern among young people in Western countries. While most young binge drinkers are not clinically alcohol dependent, binge drinking has emerged as a significant social and public health concern. The circulating alcohol consumed during binge episodes permeates cellular membranes throughout the body, exerting profound effects on multiple organs, and signaling pathways. Regular binge drinking eventually induces hepatic steatosis (fatty liver), initiates acute inflammation, and accelerates neutrophil infiltration, de novo lipogenesis, adipocyte death/lipolysis, and the production of nonoxidative alcohol metabolites, processes that synergize to damage liver tissue and impair liver function. Metabolic abnormalities such as diabetes and obesity can also exacerbate the progression of alcohol-related liver disease among binge drinkers. Several animal models have been developed to evaluate the pathophysiological changes resulting from binge drinking; however, the pathogenesis of binge drinking is not fully understood due to differences in alcohol metabolism between animal models and humans. Thus, given the high prevalence and severe health implications of binge drinking, there is an urgent need for comprehensive experimental and clinical investigations to unravel the associated pathophysiological changes. This review summarizes recent research findings on the impact of binge drinking, specifically focusing on its contributions to alcoholic liver injury.

酗酒对酒精性肝病的影响。
大量的研究已经检测了慢性酒精(乙醇)消耗引起的病理生理变化及其潜在机制,而对酗酒对健康的影响的了解却很少。狂饮被定义为在单次饮酒期间过量饮酒,是西方国家年轻人的典型消费模式。虽然大多数酗酒的年轻人临床上并不依赖酒精,但酗酒已经成为一个重大的社会和公共卫生问题。暴饮暴食期间循环消耗的酒精渗透到全身的细胞膜,对多个器官和信号通路产生深远的影响。经常酗酒最终会导致肝脂肪变性(脂肪肝),引发急性炎症,加速中性粒细胞浸润、脂肪新生、脂肪细胞死亡/脂肪分解,以及非氧化性酒精代谢物的产生,这些过程协同作用损害肝组织,损害肝功能。代谢异常,如糖尿病和肥胖,也会加剧酗酒者酒精相关肝病的发展。已经建立了几种动物模型来评估酗酒引起的病理生理变化;然而,由于动物模型与人类酒精代谢的差异,酗酒的发病机制尚不完全清楚。因此,鉴于酗酒的高患病率和严重的健康影响,迫切需要全面的实验和临床研究来揭示相关的病理生理变化。这篇综述总结了最近关于酗酒影响的研究成果,特别关注它对酒精性肝损伤的贡献。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
13.40
自引率
9.00%
发文量
48
审稿时长
3.3 months
期刊介绍: Archives of Pharmacal Research is the official journal of the Pharmaceutical Society of Korea and has been published since 1976. Archives of Pharmacal Research is an interdisciplinary journal devoted to the publication of original scientific research papers and reviews in the fields of drug discovery, drug development, and drug actions with a view to providing fundamental and novel information on drugs and drug candidates.
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