Effects of simultaneous multislice acceleration on the stability of radiomics features in parametric maps of IVIM and DKI in uterine cervical cancer

IF 2 4区医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Journal of Applied Clinical Medical Physics Pub Date : 2025-03-02 DOI:10.1002/acm2.70063

Shuangquan Ai, Wei Peng, Rong Hou, Huiting Zhang, Robert Grimm, Zilong Yuan, Yulin Liu

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引用次数: 0

Abstract

Purpose

The aim of this study was to investigate the influence of the simultaneous multislice acceleration (SMS) technique as well as two-dimensional (2D) and three-dimensional (3D) tumor segmentations on radiomics features (RFs) within the parametric maps of cervical cancer, which were computed by intravoxel incoherent motion (IVIM) and diffusion kurtosis imaging (DKI). Additionally, the study sought to identify those RFs that could characterize the clinical stages (low-stage vs. high-stage) of cervical cancer.

Materials and methods

Multi-b-value diffusion-weighted imaging (DWI) of 40 patients with cervical cancer were collected using the SMS technique with acceleration factors (AF) of 1–3. RFs were extracted from parametric maps representing pure diffusion coefficient (D), pseudodiffusion coefficient (D*), perfusion fraction (f), mean diffusivity (MD), and mean kurtosis (MK). A total of 93 2D and 93 3D RFs were extracted from per parametric map. The concordance correlation coefficient (CCC) and coefficients of variation (COV) were used to jointly assess the stability of features. Finally, the intra-class correlation coefficient (ICC) was used for intra-group consistency assessment. Receiver operating characteristic (ROC) curve was used to evaluate diagnostic performance of stable features in distinguishing lower and higher stages.

Results

Feature stability decreased with higher AF. Among these features, 9.1% of 2D and 12.7% of 3D RFs were stable (CCC > 0.9 and COV ≤ 0.1). ADC maps had the highest stability, whileas D^* and f maps had the lowest stability and 3D features were more stable than 2D features. A total of 5 2D and 25 3D stable features were identified that could distinguish lower and higher stages (AUC = 0.66–0.83).

Conclusion

SMS demonstrated impact on the stability of RFs in IVIM and DKI parametric maps, particularly for D* and f maps. Multi-b-value DWI with SMS (AF = 2) was recommended for clinical radiomics research.

Abstract Image

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同时多层加速对子宫癌IVIM和DKI参数图放射组学特征稳定性的影响

目的：本研究的目的是探讨同步多层加速（SMS）技术以及二维（2D）和三维（3D）肿瘤分割对宫颈癌参数图中放射组学特征（rf）的影响，这些参数图是由体素内非相干运动（IVIM）和扩散峰度成像（DKI）计算的。此外，该研究还试图确定那些能够表征宫颈癌临床分期（低分期与高分期）的RFs。材料与方法：收集40例宫颈癌患者的多b值弥散加权成像（DWI），采用加速因子（AF）为1-3的SMS技术。从代表纯扩散系数(D)、伪扩散系数（D*）、灌注分数(f)、平均扩散系数（MD）和平均峰度（MK）的参数图中提取rf。每个参数图共提取了93个2D和93个3D rf。采用一致性相关系数（CCC）和变异系数（COV）联合评价特征的稳定性。最后，采用类内相关系数（ICC）进行组内一致性评价。采用受试者工作特征（ROC）曲线评价稳定特征在区分高低分期中的诊断效能。结果：AF越高，特征稳定性越差。其中，9.1%的2D特征稳定，12.7%的3D特征稳定（CCC > 0.9, COV≤0.1）。ADC图的稳定性最高，D*和f图的稳定性最低，3D特征比2D特征更稳定。共识别出5个二维稳定特征和25个三维稳定特征，可以区分高低阶段（AUC = 0.66 ~ 0.83）。结论：SMS对IVIM和DKI参数图中RFs的稳定性有影响，特别是对D*和f图。多b值DWI与SMS （AF = 2）推荐用于临床放射组学研究。

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来源期刊

Journal of Applied Clinical Medical Physics 医学-核医学

CiteScore

3.60

自引率

19.00%

发文量

331

审稿时长

3 months

期刊介绍： Journal of Applied Clinical Medical Physics is an international Open Access publication dedicated to clinical medical physics. JACMP welcomes original contributions dealing with all aspects of medical physics from scientists working in the clinical medical physics around the world. JACMP accepts only online submission. JACMP will publish: -Original Contributions: Peer-reviewed, investigations that represent new and significant contributions to the field. Recommended word count: up to 7500. -Review Articles: Reviews of major areas or sub-areas in the field of clinical medical physics. These articles may be of any length and are peer reviewed. -Technical Notes: These should be no longer than 3000 words, including key references. -Letters to the Editor: Comments on papers published in JACMP or on any other matters of interest to clinical medical physics. These should not be more than 1250 (including the literature) and their publication is only based on the decision of the editor, who occasionally asks experts on the merit of the contents. -Book Reviews: The editorial office solicits Book Reviews. -Announcements of Forthcoming Meetings: The Editor may provide notice of forthcoming meetings, course offerings, and other events relevant to clinical medical physics. -Parallel Opposed Editorial: We welcome topics relevant to clinical practice and medical physics profession. The contents can be controversial debate or opposed aspects of an issue. One author argues for the position and the other against. Each side of the debate contains an opening statement up to 800 words, followed by a rebuttal up to 500 words. Readers interested in participating in this series should contact the moderator with a proposed title and a short description of the topic