Effects of simultaneous multislice acceleration on the stability of radiomics features in parametric maps of IVIM and DKI in uterine cervical cancer.

IF 2 4区医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Journal of Applied Clinical Medical Physics Pub Date : 2025-03-02 DOI:10.1002/acm2.70063

Shuangquan Ai, Wei Peng, Rong Hou, Huiting Zhang, Robert Grimm, Zilong Yuan, Yulin Liu

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引用次数: 0

Abstract

Purpose: The aim of this study was to investigate the influence of the simultaneous multislice acceleration (SMS) technique as well as two-dimensional (2D) and three-dimensional (3D) tumor segmentations on radiomics features (RFs) within the parametric maps of cervical cancer, which were computed by intravoxel incoherent motion (IVIM) and diffusion kurtosis imaging (DKI). Additionally, the study sought to identify those RFs that could characterize the clinical stages (low-stage vs. high-stage) of cervical cancer.

Materials and methods: Multi-b-value diffusion-weighted imaging (DWI) of 40 patients with cervical cancer were collected using the SMS technique with acceleration factors (AF) of 1-3. RFs were extracted from parametric maps representing pure diffusion coefficient (D), pseudodiffusion coefficient (D*), perfusion fraction (f), mean diffusivity (MD), and mean kurtosis (MK). A total of 93 2D and 93 3D RFs were extracted from per parametric map. The concordance correlation coefficient (CCC) and coefficients of variation (COV) were used to jointly assess the stability of features. Finally, the intra-class correlation coefficient (ICC) was used for intra-group consistency assessment. Receiver operating characteristic (ROC) curve was used to evaluate diagnostic performance of stable features in distinguishing lower and higher stages.

Results: Feature stability decreased with higher AF. Among these features, 9.1% of 2D and 12.7% of 3D RFs were stable (CCC > 0.9 and COV ≤ 0.1). ADC maps had the highest stability, whileas D^* and f maps had the lowest stability and 3D features were more stable than 2D features. A total of 5 2D and 25 3D stable features were identified that could distinguish lower and higher stages (AUC = 0.66-0.83).

Conclusion: SMS demonstrated impact on the stability of RFs in IVIM and DKI parametric maps, particularly for D* and f maps. Multi-b-value DWI with SMS (AF = 2) was recommended for clinical radiomics research.

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来源期刊

Journal of Applied Clinical Medical Physics 医学-核医学

CiteScore

3.60

自引率

19.00%

发文量

331

审稿时长

3 months

期刊介绍： Journal of Applied Clinical Medical Physics is an international Open Access publication dedicated to clinical medical physics. JACMP welcomes original contributions dealing with all aspects of medical physics from scientists working in the clinical medical physics around the world. JACMP accepts only online submission. JACMP will publish: -Original Contributions: Peer-reviewed, investigations that represent new and significant contributions to the field. Recommended word count: up to 7500. -Review Articles: Reviews of major areas or sub-areas in the field of clinical medical physics. These articles may be of any length and are peer reviewed. -Technical Notes: These should be no longer than 3000 words, including key references. -Letters to the Editor: Comments on papers published in JACMP or on any other matters of interest to clinical medical physics. These should not be more than 1250 (including the literature) and their publication is only based on the decision of the editor, who occasionally asks experts on the merit of the contents. -Book Reviews: The editorial office solicits Book Reviews. -Announcements of Forthcoming Meetings: The Editor may provide notice of forthcoming meetings, course offerings, and other events relevant to clinical medical physics. -Parallel Opposed Editorial: We welcome topics relevant to clinical practice and medical physics profession. The contents can be controversial debate or opposed aspects of an issue. One author argues for the position and the other against. Each side of the debate contains an opening statement up to 800 words, followed by a rebuttal up to 500 words. Readers interested in participating in this series should contact the moderator with a proposed title and a short description of the topic