Two Faces of NOTCH1 in Liver Cancer and Immunotherapy.

IF 29.7 1区医学 Q1 ONCOLOGY

Cancer discovery Pub Date : 2025-03-03 DOI:10.1158/2159-8290.CD-24-1883

Jiani Zhu, Ekaterina K Koltsova

引用次数: 0

Abstract

High NOTCH1 expression inversely correlates with hepatocellular carcinoma tumorigenicity and contributes to better immune checkpoint inhibitor responses in male patients, whereas high NOTCH1 in females coincides with heightened hepatocellular carcinoma incidence and poor immunotherapy responses. Activated NOTCH1 generates enhanced antitumor CD8+ T-cell responses in a sex chromosome-dependent manner and facilitates responsiveness to immunotherapy treatment in males, whereas it drives immune escape in females. See related article by Lindblad et al., p. 495.

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NOTCH1的高表达与肝细胞癌的致瘤性成反比，并有助于男性患者对免疫检查点抑制剂产生更好的反应，而女性NOTCH1的高表达则与肝细胞癌发病率增高和免疫疗法反应不佳相吻合。活化的NOTCH1以性染色体依赖的方式产生增强的抗肿瘤CD8+ T细胞反应，并促进男性对免疫疗法治疗的反应，而女性则会导致免疫逃逸。参见 Lindblad 等人的相关文章，第 495 页。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer discovery ONCOLOGY-

CiteScore

22.90

自引率

1.40%

发文量

838

审稿时长

6-12 weeks

期刊介绍： Cancer Discovery publishes high-impact, peer-reviewed articles detailing significant advances in both research and clinical trials. Serving as a premier cancer information resource, the journal also features Review Articles, Perspectives, Commentaries, News stories, and Research Watch summaries to keep readers abreast of the latest findings in the field. Covering a wide range of topics, from laboratory research to clinical trials and epidemiologic studies, Cancer Discovery spans the entire spectrum of cancer research and medicine.