Decoding the Nectin Interactome: Implications for Brain Development, Plasticity, and Neurological Disorders.

IF 4.1 3区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
ACS Chemical Neuroscience Pub Date : 2025-03-19 Epub Date: 2025-03-02 DOI:10.1021/acschemneuro.5c00069
Shreyash Santosh Yadav, Krishnamoorthy Srinivasan, Shyam Sunder Sharma, Ashok Kumar Datusalia
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引用次数: 0

Abstract

The nectin family of cell adhesion molecules (CAMs) comprising nectins and nectin-like molecules has emerged as a key regulator of various pivotal neural processes, including neuronal development, migration, synapse formation, and plasticity. Nectins engage in homophilic and heterophilic interactions to mediate cell-cell adhesion, contributing to the establishment and maintenance of neural circuits. Their extracellular domains facilitate trans-synaptic interactions, while intracellular domains participate in signaling cascades influencing cytoskeletal dynamics and synaptic function. The exhibition of distinct localization patterns in neurons, astrocytes, and the blood-brain barrier underscores their diverse roles in the brain. The dysregulation of nectins has been implicated in several neurological disorders, such as neurodevelopmental disorders, depression, schizophrenia, and Alzheimer's disease. This review examines the structural and functional characteristics of nectins and their distribution and molecular mechanisms governing neural connectivity and cognition. It further discusses experimental studies unraveling nectin-mediated pathophysiology and potential therapeutic interventions targeting nectin-related pathways. Collectively, this comprehensive analysis highlights the significance of nectins in brain development, function, and disorders, paving the way for future research directions and clinical implications.

解码连接蛋白相互作用组:对大脑发育、可塑性和神经系统疾病的影响。
由连接素和连接素样分子组成的细胞粘附分子(CAMs)连接素家族已经成为各种关键神经过程的关键调节剂,包括神经元发育、迁移、突触形成和可塑性。连接蛋白参与嗜同性和嗜异性的相互作用,介导细胞间的粘附,有助于神经回路的建立和维持。它们的胞外结构域促进跨突触相互作用,而胞内结构域参与影响细胞骨架动力学和突触功能的信号级联反应。神经元、星形胶质细胞和血脑屏障中不同的定位模式强调了它们在大脑中的不同作用。连接素的失调与几种神经系统疾病有关,如神经发育障碍、抑郁症、精神分裂症和阿尔茨海默病。本文综述了连接蛋白的结构和功能特征、分布及其调控神经连接和认知的分子机制。它进一步讨论了实验研究揭示了连接蛋白介导的病理生理和潜在的治疗干预针对连接蛋白相关途径。总的来说,这一综合分析突出了连接蛋白在大脑发育、功能和疾病中的重要性,为未来的研究方向和临床意义铺平了道路。
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来源期刊
ACS Chemical Neuroscience
ACS Chemical Neuroscience BIOCHEMISTRY & MOLECULAR BIOLOGY-CHEMISTRY, MEDICINAL
CiteScore
9.20
自引率
4.00%
发文量
323
审稿时长
1 months
期刊介绍: ACS Chemical Neuroscience publishes high-quality research articles and reviews that showcase chemical, quantitative biological, biophysical and bioengineering approaches to the understanding of the nervous system and to the development of new treatments for neurological disorders. Research in the journal focuses on aspects of chemical neurobiology and bio-neurochemistry such as the following: Neurotransmitters and receptors Neuropharmaceuticals and therapeutics Neural development—Plasticity, and degeneration Chemical, physical, and computational methods in neuroscience Neuronal diseases—basis, detection, and treatment Mechanism of aging, learning, memory and behavior Pain and sensory processing Neurotoxins Neuroscience-inspired bioengineering Development of methods in chemical neurobiology Neuroimaging agents and technologies Animal models for central nervous system diseases Behavioral research
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