NeoCoMM: Neocortical neuro-inspired computational model for realistic microscale simulations

IF 2.4 4区计算机科学 Q2 COMPUTER SCIENCE, SOFTWARE ENGINEERING

SoftwareX Pub Date : 2025-03-03 DOI:10.1016/j.softx.2025.102108

Mariam Al Harrach , Maxime Yochum , Fabrice Wendling

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引用次数: 0

Abstract

The ability to simulate a neocortical neural network activity at the cellular level is of great interest in many studies. It allows for the investigation of microscopic mechanisms in both healthy and pathological brains. Microscale models of cortical volumes already exist however they are either too complex to use or too phenomenological to portray accurate results. NeoCoMM(The Neocortical Computational Microscale model) is an innovative and realistic microscale software application. It offers a friendly graphical user interface that allows for the simulation of the intracellular (single cell) and extracellular (local field potential) neural activity of a cortical column. This software provides a realistic framework that can portray the neural activity and underlying cellular mechanisms related to different brain pathologies such as epilepsy. NeoCoMM is capable of (1) simulating the cortical tissue of three different species, (2) visualizing individual cell responses to external stimulation, (3) visualizing the corresponding local field potential, (4) studying the impact of the recording electrode features on simulated signals, and (5) testing various physiological and pathological hypotheses. While NeoCoMM was primarily developed for simulating epileptiform activity, it can also generate healthy brain rhythms or be adapted to other brain disorders.

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来源期刊

SoftwareX COMPUTER SCIENCE, SOFTWARE ENGINEERING-

CiteScore

5.50

自引率

2.90%

发文量

184

审稿时长

9 weeks

期刊介绍： SoftwareX aims to acknowledge the impact of software on today''s research practice, and on new scientific discoveries in almost all research domains. SoftwareX also aims to stress the importance of the software developers who are, in part, responsible for this impact. To this end, SoftwareX aims to support publication of research software in such a way that: The software is given a stamp of scientific relevance, and provided with a peer-reviewed recognition of scientific impact; The software developers are given the credits they deserve; The software is citable, allowing traditional metrics of scientific excellence to apply; The academic career paths of software developers are supported rather than hindered; The software is publicly available for inspection, validation, and re-use. Above all, SoftwareX aims to inform researchers about software applications, tools and libraries with a (proven) potential to impact the process of scientific discovery in various domains. The journal is multidisciplinary and accepts submissions from within and across subject domains such as those represented within the broad thematic areas below: Mathematical and Physical Sciences; Environmental Sciences; Medical and Biological Sciences; Humanities, Arts and Social Sciences. Originating from these broad thematic areas, the journal also welcomes submissions of software that works in cross cutting thematic areas, such as citizen science, cybersecurity, digital economy, energy, global resource stewardship, health and wellbeing, etcetera. SoftwareX specifically aims to accept submissions representing domain-independent software that may impact more than one research domain.