The epidemiology, pathology and pathogenesis of MS: Therapeutic implications.

IF 5.6 2区医学 Q1 CLINICAL NEUROLOGY

Neurotherapeutics Pub Date : 2025-02-27 DOI:10.1016/j.neurot.2025.e00539

Douglas S Goodin

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引用次数: 0

Abstract

Multiple sclerosis (MS) is a chronic, and potentially disabling, inflammatory disease of the central nervous system (CNS). MS is generally characterized by recurrent, and self-limited, episodes of neurological dysfunction, which occur unpredictably and often result in multifocal tissue injury within the CNS. Currently, women are affected two to three times as often as men although this may not have been the case during earlier Time-Periods. The pathogenesis of MS is known to involve both critical genetic and environmental mechanisms. Nevertheless, in addition to these two mechanisms, disease-pathogenesis also involves a "truly" random event. Indeed, it is this random mechanism, which is responsible for the currently-observed (and increasing) excess of women among patients with MS. This review summarizes the current state of knowledge regarding the pathogenesis of MS (includong its epidemiology, pathology, and genetics) and considers the therapeutic implications that these pathogenetic mechanisms have both for our currently available therapies as well as for the possible therapeutic approaches to the management of this potentially disabling condition in the future.

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多发性硬化症的流行病学、病理和发病机制：治疗意义。

多发性硬化症（MS）是一种慢性、潜在致残的中枢神经系统（CNS）炎症性疾病。多发性硬化症通常以复发性、自限性神经功能障碍发作为特征，这些发作不可预测，经常导致中枢神经系统内的多灶性组织损伤。目前，女性受到影响的频率是男性的两到三倍，尽管在较早的时期可能不是这种情况。已知多发性硬化症的发病机制涉及关键的遗传和环境机制。然而，除了这两种机制外，疾病发病机制还涉及“真正的”随机事件。事实上，正是这种随机机制导致了目前观察到的（并且不断增加的）MS患者中女性过多。本文综述了目前关于MS发病机制的知识现状(包括其流行病学，病理学，和遗传学)，并考虑这些致病机制对我们目前可用的治疗方法以及未来可能的治疗方法的治疗意义，以管理这种潜在的致残状况。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurotherapeutics 医学-神经科学

CiteScore

11.00

自引率

3.50%

发文量

154

审稿时长

6-12 weeks

期刊介绍： Neurotherapeutics® is the journal of the American Society for Experimental Neurotherapeutics (ASENT). Each issue provides critical reviews of an important topic relating to the treatment of neurological disorders written by international authorities. The Journal also publishes original research articles in translational neuroscience including descriptions of cutting edge therapies that cross disciplinary lines and represent important contributions to neurotherapeutics for medical practitioners and other researchers in the field. Neurotherapeutics ® delivers a multidisciplinary perspective on the frontiers of translational neuroscience, provides perspectives on current research and practice, and covers social and ethical as well as scientific issues.