Solubility and thermodynamic properties of amlodipine besylate in two binary mixtures of n-methyl pyrrolidone+1-propanol/2-propanol at different temperatures.

IF 1 Q4 PHARMACOLOGY & PHARMACY

Annales pharmaceutiques francaises Pub Date : 2025-02-26 DOI:10.1016/j.pharma.2025.02.009

Seyedmahdi Naghavi Kalajahi, Elaheh Rahimpour, Abolghasem Jouyban

引用次数: 0

Abstract

In this study, the solubility of amlodipine besylate in N-methyl-pyrrolidone/1-propanol and N-methyl-pyrrolidone/2-propanol binary mixture systems were measured using a common shake-flask method followed by spectroscopy analysis at temperature ranges from 298.2K to 313.2K. The generated data were fitted to some models, van't Hoff, Jouyban-Acree, Jouyban-Acree-van't Hoff, mixture response surface, and modified Wilson, to mathematical representation the solubility data. Finally, the apparent thermodynamics properties for the saturated mixtures were computed using van't Hoff and Gibbs equations.

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来源期刊

Annales pharmaceutiques francaises PHARMACOLOGY & PHARMACY-

CiteScore

1.70

自引率

7.70%

发文量

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