Photodynamic anti-cancer therapy and arachidonic acid metabolism: State of the art in 2024.

IF 1 Q4 PHARMACOLOGY & PHARMACY

Annales pharmaceutiques francaises Pub Date : 2025-02-26 DOI:10.1016/j.pharma.2025.02.010

Hicham Wahnou, Youness Limami, Raphaël Emmanuel Duval, Bassel Ismail, David Yannick Léger, Vincent Sol, Bertrand Liagre

{"title":"Photodynamic anti-cancer therapy and arachidonic acid metabolism: State of the art in 2024.","authors":"Hicham Wahnou, Youness Limami, Raphaël Emmanuel Duval, Bassel Ismail, David Yannick Léger, Vincent Sol, Bertrand Liagre","doi":"10.1016/j.pharma.2025.02.010","DOIUrl":null,"url":null,"abstract":"<p><p>Photodynamic therapy (PDT) has emerged as a promising and evolving modality in cancer treatment leveraging light-sensitive compounds known as photosensitizers to selectively induce cell death in malignant tissues through the generation of reactive oxygen species (ROS). This review delves into the intricate mechanisms of PDT highlighting the pivotal role of photosensitizers and the resultant oxidative stress that damages cancer cells. It explores the versatile applications of PDT across various cancer types alongside the advantages and limitations inherent to this therapy. Recent technological advancements including improved photosensitizers and novel light delivery systems are also discussed. Additionally the review examines the critical role of arachidonic acid (AA) metabolism in cancer progression detailing the cyclooxygenase, lipoxygenase and cytochrome P450 pathways and their contributions to tumor biology. By elucidating the interplay between PDT and AA metabolism the review underscores the potential of targeting AA metabolic pathways to enhance PDT efficacy. Finally it provides clinical and translational perspectives highlighting ongoing research and future directions aimed at optimizing PDT for improved cancer treatment outcomes.</p>","PeriodicalId":8332,"journal":{"name":"Annales pharmaceutiques francaises","volume":" ","pages":""},"PeriodicalIF":1.0000,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annales pharmaceutiques francaises","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1016/j.pharma.2025.02.010","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}

引用次数: 0

Abstract

Photodynamic therapy (PDT) has emerged as a promising and evolving modality in cancer treatment leveraging light-sensitive compounds known as photosensitizers to selectively induce cell death in malignant tissues through the generation of reactive oxygen species (ROS). This review delves into the intricate mechanisms of PDT highlighting the pivotal role of photosensitizers and the resultant oxidative stress that damages cancer cells. It explores the versatile applications of PDT across various cancer types alongside the advantages and limitations inherent to this therapy. Recent technological advancements including improved photosensitizers and novel light delivery systems are also discussed. Additionally the review examines the critical role of arachidonic acid (AA) metabolism in cancer progression detailing the cyclooxygenase, lipoxygenase and cytochrome P450 pathways and their contributions to tumor biology. By elucidating the interplay between PDT and AA metabolism the review underscores the potential of targeting AA metabolic pathways to enhance PDT efficacy. Finally it provides clinical and translational perspectives highlighting ongoing research and future directions aimed at optimizing PDT for improved cancer treatment outcomes.

查看原文本刊更多论文

光动力抗癌疗法与花生四烯酸代谢：2024 年的技术水平。

光动力疗法（PDT）是一种前景广阔、不断发展的癌症治疗方法，它利用被称为光敏剂的光敏化合物，通过产生活性氧（ROS）选择性地诱导恶性组织细胞死亡。本综述深入探讨了光化学疗法的复杂机制，强调了光敏剂的关键作用以及由此产生的损伤癌细胞的氧化应激。它探讨了光动力疗法在各种癌症类型中的广泛应用，以及这种疗法固有的优势和局限性。还讨论了最近的技术进步，包括改进的光敏剂和新型光传输系统。此外，该综述还研究了花生四烯酸（AA）代谢在癌症进展中的关键作用，详细介绍了环氧化酶、脂氧合酶和细胞色素 P450 途径及其对肿瘤生物学的贡献。通过阐明光动力疗法与 AA 代谢之间的相互作用，该综述强调了针对 AA 代谢途径提高光动力疗法疗效的潜力。最后，它从临床和转化的角度强调了正在进行的研究和未来的发展方向，旨在优化 PDT 以改善癌症治疗效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Annales pharmaceutiques francaises PHARMACOLOGY & PHARMACY-

CiteScore

1.70

自引率

7.70%

发文量

期刊介绍： This journal proposes a scientific information validated and indexed to be informed about the last research works in all the domains interesting the pharmacy. The original works, general reviews, the focusing, the brief notes, subjected by the best academics and the professionals, propose a synthetic approach of the last progress accomplished in the concerned sectors. The thematic Sessions and the – life of the Academy – resume the communications which, presented in front of the national Academy of pharmacy, are in the heart of the current events.