Lactylation and regulated cell death

IF 3.7 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochimica et biophysica acta. Molecular cell research Pub Date : 2025-02-27 DOI:10.1016/j.bbamcr.2025.119927

Wenlong Zhang , Guangyao Shan , Guoshu Bi, Zhengyang Hu, Yanjun Yi, Dejun Zeng, Zongwu Lin, Cheng Zhan

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Abstract

Lactylation, a newly identified post-translational modification, entails the attachment of lactate to lysine residues within proteins, profoundly modulating diverse cellular mechanisms underlying regulated cell death (RCD). This modification encompasses two primary categories: histone lactylation and non-histone lactylation. Histone lactylation assumes a pivotal regulatory function in the RCD process, primarily by modulating the transcriptional landscape of genes implicated in cell death. In contrast, non-histone lactylation exerts its influence by targeting transferases, transcription, cell cycle progression, death pathways, and metabolic processes that are intricately involved in RCD. This review provides a comprehensive overview of recent breakthroughs in understanding how lactylation regulates RCD, while also offering insights into potential avenues for future research, thereby deepening our comprehension of cellular fate determination.

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乳酸化和调节细胞死亡

乳酸酰化是一种新发现的翻译后修饰，它涉及蛋白质中乳酸与赖氨酸残基的附着，深刻地调节了多种细胞机制，这些机制是调控细胞死亡（RCD）的基础。这种修饰包括两个主要类别：组蛋白乳酸化和非组蛋白乳酸化。组蛋白乳酸化在RCD过程中起着关键的调节作用，主要是通过调节与细胞死亡有关的基因的转录景观。相反，非组蛋白乳酸化通过靶向转移酶、转录、细胞周期进程、死亡途径和与RCD相关的代谢过程来发挥其影响。这篇综述全面概述了最近在理解乳酸化如何调节RCD方面的突破，同时也为未来的研究提供了潜在的途径，从而加深了我们对细胞命运决定的理解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biochimica et biophysica acta. Molecular cell research 生物-生化与分子生物学

CiteScore

10.00

自引率

2.00%

发文量

151

审稿时长

44 days

期刊介绍： BBA Molecular Cell Research focuses on understanding the mechanisms of cellular processes at the molecular level. These include aspects of cellular signaling, signal transduction, cell cycle, apoptosis, intracellular trafficking, secretory and endocytic pathways, biogenesis of cell organelles, cytoskeletal structures, cellular interactions, cell/tissue differentiation and cellular enzymology. Also included are studies at the interface between Cell Biology and Biophysics which apply for example novel imaging methods for characterizing cellular processes.