Polymer composites with enhanced electrochemical properties and their application in non-small cell lung cancer treatment

IF 4 2区化学 Q2 CHEMISTRY, PHYSICAL

Journal of Molecular Structure Pub Date : 2025-02-21 DOI:10.1016/j.molstruc.2025.141813

Yujun Wei , Zhiling Zhang , Tianrang Ao

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引用次数: 0

Abstract

Cancer, particularly non-small cell lung cancer (NSCLC), remains a leading cause of cancer-related deaths, with a dismal 5-year survival rate of approximately 15 %. This underscores the urgent need for novel, safe, and effective targeted therapies. In this study, we synthesized compound 1 for lung cancer treatment, considering the challenges in drug delivery. A new three-dimensional (3D) La(III)-based coordination polymer with the chemical composition of {[La(L)(H₂O)₃]Cl·H₂O}_n (1) (H₂L = (4-(pyridyl-N-oxide)methylphosphonic acid), was successfully self-assembled via diffusion method at room temperature and characterized by single-crystal X-ray diffraction, elemental analyses and FT-IR. Following this, we developed a composite drug delivery material, PCL-CB@CP1@1, and assessed its inhibitory effects on NSCLC cell proliferation. The results demonstrated that PCL-CB@CP1@1 effectively inhibited cell growth by modulating the Nrf2/HO-1/GPX4 signaling pathway. Additionally, molecular docking simulations indicated multiple binding interactions between the La(III) complex and receptor sites, further highlighting its significant biological activity. These findings suggest that PCL-CB@CP1@1 holds potential as a targeted therapeutic agent for lung cancer treatment, offering new possibilities for improving patient outcomes.

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来源期刊

Journal of Molecular Structure 化学-物理化学

CiteScore

7.10

自引率

15.80%

发文量

2384

审稿时长

45 days

期刊介绍： The Journal of Molecular Structure is dedicated to the publication of full-length articles and review papers, providing important new structural information on all types of chemical species including: • Stable and unstable molecules in all types of environments (vapour, molecular beam, liquid, solution, liquid crystal, solid state, matrix-isolated, surface-absorbed etc.) • Chemical intermediates • Molecules in excited states • Biological molecules • Polymers. The methods used may include any combination of spectroscopic and non-spectroscopic techniques, for example: • Infrared spectroscopy (mid, far, near) • Raman spectroscopy and non-linear Raman methods (CARS, etc.) • Electronic absorption spectroscopy • Optical rotatory dispersion and circular dichroism • Fluorescence and phosphorescence techniques • Electron spectroscopies (PES, XPS), EXAFS, etc. • Microwave spectroscopy • Electron diffraction • NMR and ESR spectroscopies • Mössbauer spectroscopy • X-ray crystallography • Charge Density Analyses • Computational Studies (supplementing experimental methods) We encourage publications combining theoretical and experimental approaches. The structural insights gained by the studies should be correlated with the properties, activity and/ or reactivity of the molecule under investigation and the relevance of this molecule and its implications should be discussed.