Elevated 18:1 lysophosphatidylcholine contributes to neuropathic pain in peripheral nerve injury.

IF 5.1 2区医学 Q1 ANESTHESIOLOGY

Regional Anesthesia and Pain Medicine Pub Date : 2025-02-27 DOI:10.1136/rapm-2024-106195

Jinxuan Ren, Lina Yu, Jiaqi Lin, Ying Liu, Longfei Ma, Yangyuxin Huang, Na Sun, Yutao Deng, Da Zhong, Binglin Zhou, Baochun Jiang, Min Yan

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引用次数: 0

Abstract

Background: Neuropathic pain is a maladaptive and chronic condition with limited effective treatments. Although recent studies have suggested that certain lipid metabolites, like lysophosphatidylcholine (LPC), may contribute to chronic pain, their specific roles and mechanisms remain unclear.

Objective: This study investigated the role and mechanism of LPC(18:1), a lipid subtype, in neuropathic pain caused by nerve injury.

Methods: Using a mouse model of spinal nerve ligation, LPC(18:1) levels were measured in serum, dorsal root ganglion (DRG), spinal cord (SC) and cerebrospinal fluid (CSF). Nociception was assessed using von Frey and Hargreaves' methods, while molecular analyses explored inflammatory pathways and oxidative stress.

Results: LPC(18:1) levels significantly increased in the serum, DRG and CSF after nerve injury. Administration of LPC(18:1) induced heightened pain responses and activated inflammatory pathways, including protein kinase C (PKC) and extracellular regulated protein kinase (ERK) in the DRG, as well as glial cells in the SC. The findings suggested that oxidative stress played a role in LPC(18:1) production, and its effects were mediated by G protein-coupled receptor 132 (GPR132).

Conclusion: LPC(18:1) may serve as a potential biomarker and therapeutic target for managing neuropathic pain.

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来源期刊

Regional Anesthesia and Pain Medicine 医学-麻醉学

CiteScore

8.50

自引率

11.80%

发文量

175

审稿时长

6-12 weeks

期刊介绍： Regional Anesthesia & Pain Medicine, the official publication of the American Society of Regional Anesthesia and Pain Medicine (ASRA), is a monthly journal that publishes peer-reviewed scientific and clinical studies to advance the understanding and clinical application of regional techniques for surgical anesthesia and postoperative analgesia. Coverage includes intraoperative regional techniques, perioperative pain, chronic pain, obstetric anesthesia, pediatric anesthesia, outcome studies, and complications. Published for over thirty years, this respected journal also serves as the official publication of the European Society of Regional Anaesthesia and Pain Therapy (ESRA), the Asian and Oceanic Society of Regional Anesthesia (AOSRA), the Latin American Society of Regional Anesthesia (LASRA), the African Society for Regional Anesthesia (AFSRA), and the Academy of Regional Anaesthesia of India (AORA).