Potential of Garra rufa as a novel high-temperature resistant model fish: a review on current and future approaches.

IF 1.7 3区 生物学 Q2 ZOOLOGY
Yasuhito Shimada, Baki Aydın, Koto Kon-Nanjo, Kiki Syaputri Handayani, Victor David Nico Gultom, Oleg Simakov, Fahrurrozi, Tetsuo Kon
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引用次数: 0

Abstract

Garra rufa, commonly known as the "doctor fish", is a freshwater cyprinid native to warm regions of the Middle East. Since the late twentieth century, it has been widely utilized in spas for alternative therapeutics and fish pedicures (or manicures) for dermatological diseases such as psoriasis and eczema. Owing to its unique characteristics, there is growing interest in exploring various applications of G. rufa. This review provides a comprehensive summary of the phylogenetic position, ecology, biological characteristics, and breeding methods of G. rufa, and provides insights into its use as a therapeutic fish. Notably, the ability of G. rufa to thrive in high-temperature environments exceeding 37 °C distinguishes it from other cyprinids and suggests its potential as a model for human diseases, such as human infectious diseases, and in use in cancer xenograft models for high-throughput drug screening. The ongoing genome sequencing project for G. rufa aims to elucidate the mechanisms underlying its high-temperature tolerance and offers valuable genomic resources. These efforts have resulted in significant advances in fish aquaculture, species conservation, and biomedical research.

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来源期刊
Zoological Letters
Zoological Letters Agricultural and Biological Sciences-Animal Science and Zoology
CiteScore
3.60
自引率
0.00%
发文量
12
审稿时长
10 weeks
期刊介绍: Zoological Letters is an open access journal that publishes new and important findings in the zoological sciences. As a sister journal to Zoological Science, Zoological Letters covers a wide range of basic fields of zoology, from taxonomy to bioinformatics. We also welcome submissions of paleontology reports as part of our effort to contribute to the development of new perspectives in evolutionary zoology. Our goal is to serve as a global publishing forum for fundamental researchers in all fields of zoology.
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