Christopher C Jackson, Jia Jenny Liu, Howard Y Liu, Steven G Williams, Asim Anees, Zainab Noor, Natasha Lucas, Dylan Xavier, Peter G Hains, Daniel Bucio-Noble, Adel T Aref, Sandro V Porceddu, Rahul Ladwa, Joseph Whitfield, Roger R Reddel, Qing Zhong, Benedict J Panizza, Phillip J Robinson
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引用次数: 0
Abstract
Significance: HPV+OPSCC incidence is increasing, with heterogeneous treatment outcomes despite favorable prognosis. Current de-escalation strategies show inferior results, highlighting the need for precise risk stratification. Using data-independent acquisition mass spectrometry proteomics, we identified a 26-peptide signature that stratifies patients into risk categories, potentially enabling personalized treatment decisions and optimal patient selection for de-escalation trials.
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