Racial Disparities and Trends in Outcomes of Patients with Gastrointestinal Stromal Tumors.

IF 1.6 Q4 ONCOLOGY

Journal of Gastrointestinal Cancer Pub Date : 2025-02-28 DOI:10.1007/s12029-025-01195-y

Peixu Lin, Meichen Ji, Tiantian Sun, Huanhuan Sun, Haiqing Ma

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引用次数: 0

Abstract

Background: Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor of the gastrointestinal tract. However, there are limited studies on the latest survival trends and the impact of racial disparities on GIST patients' outcomes.

Methods: We obtained 12,808 GIST patients between 2001 and 2020 from the Surveillance, Epidemiology, and End Results (SEER) database in 17 original sites. Analysis utilizing the Kaplan-Meier method explored survival disparities and Cox regression was employed to assess the impact of prognostic factors.

Results: Our study revealed an increase in the GIST incidence per 100,000 people over the past two decades, along with a rise in relative survival rate (RSR). Age, gender, social groups, tumor site, size, stage, socioeconomic status, marital status, surgery, and systemic therapy are prognostic factors. Subgroup analysis indicated higher incidence and poorer survival trends among Non-Hispanic Blacks (NHB) (Incidence, 1.88 per 100,000 people; 120 Mo RSR, 61.6%, 2001 to 2020). Colonic GIST has the worst prognosis among different locations, while rectal and anal GIST has the best. Within these groups, Non-Hispanic White (NHW) with colonic GIST have the poorest prognosis (HR, 2.032; 95% CI, 1.476-2.798), whereas NHB with rectal and anal GIST have the best prognosis.

Conclusion: The incidence and RSR of GIST both increased during 2001-2020. NHW with colonic GIST showed poorer survival, while NHB with rectal and anal GIST revealed better survival, highlighting the importance of targeted clinical management for GIST.

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胃肠道间质瘤患者预后的种族差异和趋势。

背景：胃肠道间质瘤（GIST）是最常见的胃肠道间质肿瘤。然而，关于最新生存趋势和种族差异对GIST患者预后影响的研究有限。方法：我们从17个原始站点的监测、流行病学和最终结果（SEER）数据库中获得2001年至2020年期间12,808例GIST患者。Kaplan-Meier法分析生存差异，Cox回归法评估预后因素的影响。结果：我们的研究显示，在过去的20年里，每10万人中GIST的发病率有所增加，相对存活率（RSR）也有所上升。年龄、性别、社会群体、肿瘤部位、大小、分期、社会经济地位、婚姻状况、手术和全身治疗是影响预后的因素。亚组分析显示，非西班牙裔黑人（NHB）的发病率更高，生存趋势更差(发病率，1.88 / 10万人；120莫RSR， 61.6%， 2001 - 2020年)。不同部位间质瘤的预后最差，而直肠和肛门间质瘤的预后最好。在这些组中，非西班牙裔白人（Non-Hispanic White， NHW）结肠GIST预后最差(HR, 2.032；95% CI, 1.476-2.798)，而NHB合并直肠和肛门GIST的预后最好。结论：2001-2020年胃肠道间质瘤的发病率和RSR均呈上升趋势。伴有结肠GIST的NHW生存率较低，而伴有直肠和肛门GIST的NHB生存率较好，这突出了GIST靶向临床管理的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Gastrointestinal Cancer ONCOLOGY-

CiteScore

3.80

自引率

0.00%

发文量

121

期刊介绍： The Journal of Gastrointestinal Cancer is a multidisciplinary medium for the publication of novel research pertaining to cancers arising from the gastrointestinal tract.The journal is dedicated to the most rapid publication possible.The journal publishes papers in all relevant fields, emphasizing those studies that are helpful in understanding and treating cancers affecting the esophagus, stomach, liver, gallbladder and biliary tree, pancreas, small bowel, large bowel, rectum, and anus. In addition, the Journal of Gastrointestinal Cancer publishes basic and translational scientific information from studies providing insight into the etiology and progression of cancers affecting these organs. New insights are provided from diverse areas of research such as studies exploring pre-neoplastic states, risk factors, epidemiology, genetics, preclinical therapeutics, surgery, radiation therapy, novel medical therapeutics, clinical trials, and outcome studies.In addition to reports of original clinical and experimental studies, the journal also publishes: case reports, state-of-the-art reviews on topics of immediate interest or importance; invited articles analyzing particular areas of pancreatic research and knowledge; perspectives in which critical evaluation and conflicting opinions about current topics may be expressed; meeting highlights that summarize important points presented at recent meetings; abstracts of symposia and conferences; book reviews; hypotheses; Letters to the Editors; and other items of special interest, including:Complex Cases in GI Oncology: This is a new initiative to provide a forum to review and discuss the history and management of complex and involved gastrointestinal oncology cases. The format will be similar to a teaching case conference where a case vignette is presented and is followed by a series of questions and discussion points. A brief reference list supporting the points made in discussion would be expected.